phosphoric acid mono-(1-{4-[(S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2,6-difluorophenyl}-4-methoxymethyl-piperidin-4-yl) ester L-arginine salt

Base Information

Chemical Name:phosphoric acid mono-(1-{4-[(S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2,6-difluorophenyl}-4-methoxymethyl-piperidin-4-yl) ester L-arginine salt
CAS No.:1016650-87-5
Molecular Formula:C₆H₁₄N₄O₂*C₁₉H₂₆F₂N₃O₈P
Molecular Weight:667.604
Hs Code.:

phosphoric acid mono-(1-{4-[(S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2,6-difluorophenyl}-4-methoxymethyl-piperidin-4-yl) ester L-arginine salt

Synonyms:phosphoric acid mono-(1-{4-[(S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2,6-difluorophenyl}-4-methoxymethyl-piperidin-4-yl) ester L-arginine salt

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Chemical Property of phosphoric acid mono-(1-{4-[(S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2,6-difluorophenyl}-4-methoxymethyl-piperidin-4-yl) ester L-arginine salt

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Technology Process of phosphoric acid mono-(1-{4-[(S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2,6-difluorophenyl}-4-methoxymethyl-piperidin-4-yl) ester L-arginine salt

There total 3 articles about phosphoric acid mono-(1-{4-[(S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2,6-difluorophenyl}-4-methoxymethyl-piperidin-4-yl) ester L-arginine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 74-79-3,25212-18-4
L-arginine

: 1016650-82-0
phosphoric acid mono-(1-{4-[(S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2,6-difluorophenyl}-4-methoxymethyl-piperidin-4-yl) ester

: 1016650-87-5
phosphoric acid mono-(1-{4-[(S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2,6-difluorophenyl}-4-methoxymethyl-piperidin-4-yl) ester L-arginine salt

Guidance literature:: In ethanol; water; at 25 - 85 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 957796-51-9
(5S)-N-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide

: 1016650-87-5
phosphoric acid mono-(1-{4-[(S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2,6-difluorophenyl}-4-methoxymethyl-piperidin-4-yl) ester L-arginine salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-tetrazole / dichloromethane / 4 h

1.2: 4 h / 0 °C

2.1: palladium(II) hydroxide / methanol; dichloromethane; water / 6 h / 20 °C

3.1: ethanol; water / 1.5 h / 25 - 80 °C / Inert atmosphere

With 1H-tetrazole; palladium(II) hydroxide; In methanol; ethanol; dichloromethane; water;

Reference yield:

: 1016651-07-2
(S)-N-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-4-di-O-benzylphosphoryloxy-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide

: 1016650-87-5
phosphoric acid mono-(1-{4-[(S)-5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2,6-difluorophenyl}-4-methoxymethyl-piperidin-4-yl) ester L-arginine salt

Guidance literature:: Multi-step reaction with 2 steps

1: palladium(II) hydroxide / methanol; dichloromethane; water / 6 h / 20 °C

2: ethanol; water / 1.5 h / 25 - 80 °C / Inert atmosphere

palladium(II) hydroxide; In methanol; ethanol; dichloromethane; water;