methyl 1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl}benzyl)isoquinoline-4-carboxylate

Base Information

Chemical Name:methyl 1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl}benzyl)isoquinoline-4-carboxylate
CAS No.:1233249-87-0
Molecular Formula:C₂₆H₂₃ClN₂O₄S
Molecular Weight:494.999
Hs Code.:

Synonyms:methyl 1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl}benzyl)isoquinoline-4-carboxylate

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Chemical Property of methyl 1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl}benzyl)isoquinoline-4-carboxylate

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Technology Process of methyl 1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl}benzyl)isoquinoline-4-carboxylate

There total 4 articles about methyl 1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl}benzyl)isoquinoline-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1233249-86-9
tributyl(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl}benzyl)phosphonium bromide

: 37497-86-2
1-chloro-isoquinoline-4-carboxylic acid methyl ester

: 1233249-87-0
methyl 1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl}benzyl)isoquinoline-4-carboxylate

Guidance literature:: tributyl(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl}benzyl)phosphonium bromide; 1-chloro-isoquinoline-4-carboxylic acid methyl ester; With sodium hexamethyldisilazane; In tetrahydrofuran; at -30 - 50 ℃; for 3h;

With sodium carbonate; In tetrahydrofuran; water; at 50 ℃; for 2h;

Reference yield:

: 156-41-2
4-chlorophenylethylamine

: 1233249-87-0
methyl 1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl}benzyl)isoquinoline-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

2.1: 0.5 h / 60 °C

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 3 h / -30 - 50 °C

3.2: 2 h / 50 °C

With sodium hexamethyldisilazane; triethylamine; In tetrahydrofuran;

Reference yield:

: 66176-39-4
4-(bromomethyl)benzene-1-sulfonyl chloride

: 1233249-87-0
methyl 1-(4-{[2-(4-chlorophenyl)ethyl]sulfamoyl}benzyl)isoquinoline-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

2.1: 0.5 h / 60 °C

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 3 h / -30 - 50 °C

3.2: 2 h / 50 °C

With sodium hexamethyldisilazane; triethylamine; In tetrahydrofuran;