N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-(triethylsilyl)adenosin-8-yl-(8->7)-8-amino-N⁶-benzoyl-9-[6,7-dideoxy-2,3-O-isopropylidene-5-O-(triethylsilyl)-β-D-allo-hept-6-ynofuranosyl]adenine

Base Information

• Chemical Name: N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-(triethylsilyl)adenosin-8-yl-(8->7)-8-amino-N⁶-benzoyl-9-[6,7-dideoxy-2,3-O-isopropylidene-5-O-(triethylsilyl)-β-D-allo-hept-6-ynofuranosyl]adenine
• CAS No.: 328241-15-2
• Molecular Formula: C₅₄H₆₉N₁₁O₁₀Si₂
• Molecular Weight: 1088.38

Synonyms:N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-(triethylsilyl)adenosin-8-yl-(8->7)-8-amino-N⁶-benzoyl-9-[6,7-dideoxy-2,3-O-isopropylidene-5-O-(triethylsilyl)-β-D-allo-hept-6-ynofuranosyl]adenine

Chemical Property of N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-(triethylsilyl)adenosin-8-yl-(8->7)-8-amino-N⁶-benzoyl-9-[6,7-dideoxy-2,3-O-isopropylidene-5-O-(triethylsilyl)-β-D-allo-hept-6-ynofuranosyl]adenine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-(triethylsilyl)adenosin-8-yl-(8->7)-8-amino-N⁶-benzoyl-9-[6,7-dideoxy-2,3-O-isopropylidene-5-O-(triethylsilyl)-β-D-allo-hept-6-ynofuranosyl]adenine

There total 9 articles about N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-(triethylsilyl)adenosin-8-yl-(8->7)-8-amino-N⁶-benzoyl-9-[6,7-dideoxy-2,3-O-isopropylidene-5-O-(triethylsilyl)-β-D-allo-hept-6-ynofuranosyl]adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N6-benzoyl-8-iodo-2',3'-O-isopropylidene-5'-O-(triethylsilyl)adenosine (292642-46-7) + N6-benzoyl-9-[6,7-dideoxy-2,3-O-isopropylidene-5-O-(triethylsilyl)-β-D-allo-hept-6-ynofuranosyl]-8-{[(4-methoxyphenyl)methylidene]amino}adenine → N6-benzoyl-2',3'-O-isopropylidene-5'-O-(triethylsilyl)adenosin-8-yl-(8->7)-8-amino-N6-benzoyl-9-[6,7-dideoxy-2,3-O-isopropylidene-5-O-(triethylsilyl)-β-D-allo-hept-6-ynofuranosyl]adenine (328241-15-2)

Guidance literature:

With copper(l) iodide; P(fur)3; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In triethylamine; at 25 - 80 ℃; for 5h;

DOI:10.1002/1522-2675(20001220)83:12<3229::AID-HLCA3229>3.0.CO;2-S

Reference yield:

triethylsilyl chloride (994-30-9) → N6-benzoyl-2',3'-O-isopropylidene-5'-O-(triethylsilyl)adenosin-8-yl-(8->7)-8-amino-N6-benzoyl-9-[6,7-dideoxy-2,3-O-isopropylidene-5-O-(triethylsilyl)-β-D-allo-hept-6-ynofuranosyl]adenine (328241-15-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 73 percent / imidazole / dimethylformamide / 15 h / 25 °C

2: 95 percent / ethanol / 25 h / 25 °C

3: 18 percent / DDQ / CH₂Cl₂; H₂O / 4 h / 25 °C

4: 70 percent / CuI; P(fur)3 / Pd₂(dba)3 / triethylamine / 5 h / 25 - 80 °C

With 1H-imidazole; copper(l) iodide; P(fur)3; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In ethanol; dichloromethane; water; triethylamine; N,N-dimethyl-formamide;

DOI:10.1002/1522-2675(20001220)83:12<3229::AID-HLCA3229>3.0.CO;2-S

Reference yield:

N6-benzoyl-8-chloro-9-[6,7-dideoxy-2,3-O-isopropylidene-5-O-(triethylsilyl)-7-C-(trimethylsilyl)-β-D-allo-hept-6-ynofuranosyl]adenine (292642-52-5) → N6-benzoyl-2',3'-O-isopropylidene-5'-O-(triethylsilyl)adenosin-8-yl-(8->7)-8-amino-N6-benzoyl-9-[6,7-dideoxy-2,3-O-isopropylidene-5-O-(triethylsilyl)-β-D-allo-hept-6-ynofuranosyl]adenine (328241-15-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / TBAF / tetrahydrofuran / 7 h / 25 °C

2: 73 percent / imidazole / dimethylformamide / 15 h / 25 °C

3: 95 percent / ethanol / 25 h / 25 °C

4: 18 percent / DDQ / CH₂Cl₂; H₂O / 4 h / 25 °C

5: 70 percent / CuI; P(fur)3 / Pd₂(dba)3 / triethylamine / 5 h / 25 - 80 °C

With 1H-imidazole; copper(l) iodide; P(fur)3; tetrabutyl ammonium fluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; triethylamine; N,N-dimethyl-formamide;

DOI:10.1002/1522-2675(20001220)83:12<3229::AID-HLCA3229>3.0.CO;2-S

upstream raw materials:

N⁶-benzoyl-8-iodo-2',3'-O-isopropylidene-5'-O-(triethylsilyl)adenosine

triethylsilyl chloride

N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-(triethylsilyl)adenosine

N⁶-benzoyl-8-chloro-9-[6,7-dideoxy-2,3-O-isopropylidene-5-O-(triethylsilyl)-7-C-(trimethylsilyl)-β-D-allo-hept-6-ynofuranosyl]adenine

Downstream raw materials:

N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-(triethylsilyl)adenosin-8-yl-(8->7'-C)-N⁶-benzoyl-9-[6,7-dideoxy-2,3-O-isopropylidene-5-O-(triethylsilyl)-β-D-allo-hept-6-ynofuranosyl]-8-iodoadenine

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