(R)-1-(4-chlorobenzyl)-6-(ethylthio)-3-(2-methoxycarbonylpropyl)-1,3,5-triazine-2,4(1H,3H)-dion

Base Information

Chemical Name:(R)-1-(4-chlorobenzyl)-6-(ethylthio)-3-(2-methoxycarbonylpropyl)-1,3,5-triazine-2,4(1H,3H)-dion
CAS No.:1239691-23-6
Molecular Formula:C₁₇H₂₀ClN₃O₄S
Molecular Weight:397.883
Hs Code.:

Synonyms:(R)-1-(4-chlorobenzyl)-6-(ethylthio)-3-(2-methoxycarbonylpropyl)-1,3,5-triazine-2,4(1H,3H)-dion

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Chemical Property of (R)-1-(4-chlorobenzyl)-6-(ethylthio)-3-(2-methoxycarbonylpropyl)-1,3,5-triazine-2,4(1H,3H)-dion

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Technology Process of (R)-1-(4-chlorobenzyl)-6-(ethylthio)-3-(2-methoxycarbonylpropyl)-1,3,5-triazine-2,4(1H,3H)-dion

There total 3 articles about (R)-1-(4-chlorobenzyl)-6-(ethylthio)-3-(2-methoxycarbonylpropyl)-1,3,5-triazine-2,4(1H,3H)-dion which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1239691-22-5
1-(4-chlorobenzyl)-6-(ethylthio)-1,3,5-triazine-2,4-(1H,3H)-dione

: 72657-23-9,42998-03-8
methyl (R)-3-hydroxy-2-methylpropionate

: 1239691-23-6
(R)-1-(4-chlorobenzyl)-6-(ethylthio)-3-(2-methoxycarbonylpropyl)-1,3,5-triazine-2,4(1H,3H)-dion

Guidance literature:: With azodicarboxylic acid bis(2-methoxyethyl) ester; triphenylphosphine; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

: 1360105-53-8
3-(tert-butyl)-6-(ethylthio)-1,3,5-triazine-2,4(1H,3H)-dione

: 1239691-23-6
(R)-1-(4-chlorobenzyl)-6-(ethylthio)-3-(2-methoxycarbonylpropyl)-1,3,5-triazine-2,4(1H,3H)-dion

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 2 h / Inert atmosphere; Reflux

2: trifluoroacetic acid / 20 °C / Inert atmosphere

3: triphenylphosphine; azodicarboxylic acid bis(2-methoxyethyl) ester / 1,4-dioxane / 20 °C / Inert atmosphere

With azodicarboxylic acid bis(2-methoxyethyl) ester; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In 1,4-dioxane; acetonitrile; 3: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2021.128384

Reference yield:

: 3-(tert-butyl)-1-(4-chlorobenzyl)-6-(ethylthio)-1,3,5-triazine-2,4(1H,3H)-dione

: 1239691-23-6
(R)-1-(4-chlorobenzyl)-6-(ethylthio)-3-(2-methoxycarbonylpropyl)-1,3,5-triazine-2,4(1H,3H)-dion

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 20 °C / Inert atmosphere

2: triphenylphosphine; azodicarboxylic acid bis(2-methoxyethyl) ester / 1,4-dioxane / 20 °C / Inert atmosphere

With azodicarboxylic acid bis(2-methoxyethyl) ester; triphenylphosphine; trifluoroacetic acid; In 1,4-dioxane; 2: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2021.128384