(4R,5R)-3-(4-fluorophenyl)-5-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(4-hydroxyphenyl)oxazolidin-2-one

Base Information

Chemical Name:(4R,5R)-3-(4-fluorophenyl)-5-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(4-hydroxyphenyl)oxazolidin-2-one
CAS No.:1048011-45-5
Molecular Formula:C₂₄H₁₈F₂N₄O₃
Molecular Weight:448.429
Hs Code.:

Synonyms:(4R,5R)-3-(4-fluorophenyl)-5-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(4-hydroxyphenyl)oxazolidin-2-one

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Chemical Property of (4R,5R)-3-(4-fluorophenyl)-5-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(4-hydroxyphenyl)oxazolidin-2-one

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Technology Process of (4R,5R)-3-(4-fluorophenyl)-5-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(4-hydroxyphenyl)oxazolidin-2-one

There total 3 articles about (4R,5R)-3-(4-fluorophenyl)-5-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(4-hydroxyphenyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1048011-86-4
C₃₁H₂₄F₂N₄O₃

: 1048011-45-5
(4R,5R)-3-(4-fluorophenyl)-5-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(4-hydroxyphenyl)oxazolidin-2-one

Guidance literature:: With hydrogen; acetic acid; palladium 10% on activated carbon; In ethanol; at 23 ℃; for 12h; under 760.051 Torr;

Reference yield:

: C₂₃H₁₉BrFNO₃

: 1048011-45-5
(4R,5R)-3-(4-fluorophenyl)-5-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(4-hydroxyphenyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / dimethyl sulfoxide / 14 h / 23 °C

2: copper(l) iodide; hydrogen; triethylamine / water; acetonitrile / 23 °C

3: hydrogen; acetic acid / palladium 10% on activated carbon / ethanol / 12 h / 23 °C / 760.05 Torr

With copper(l) iodide; sodium azide; hydrogen; acetic acid; triethylamine; palladium 10% on activated carbon; In ethanol; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 795306-91-1
(4R,5S)-4-(4-benzyloxyphenyl)-3-(4-fluorophenyl)-2-hydroxymethyloxazolidin-2-one

: 1048011-45-5
(4R,5R)-3-(4-fluorophenyl)-5-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-4-(4-hydroxyphenyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 1 h / 23 °C

2: sodium azide / dimethyl sulfoxide / 14 h / 23 °C

3: copper(l) iodide; hydrogen; triethylamine / water; acetonitrile / 23 °C

4: hydrogen; acetic acid / palladium 10% on activated carbon / ethanol / 12 h / 23 °C / 760.05 Torr

With copper(l) iodide; sodium azide; carbon tetrabromide; hydrogen; acetic acid; triethylamine; triphenylphosphine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; acetonitrile;