ethyl 3-(3,5-dimethoxyphenyl)-4-oxo-3,3a,4,6-tetra-hydro-1H-furo[3,4-c]pyran-3a-carboxylate

Base Information

Chemical Name:ethyl 3-(3,5-dimethoxyphenyl)-4-oxo-3,3a,4,6-tetra-hydro-1H-furo[3,4-c]pyran-3a-carboxylate
CAS No.:1309359-45-2
Molecular Formula:C₁₈H₂₀O₇
Molecular Weight:348.353
Hs Code.:

Synonyms:ethyl 3-(3,5-dimethoxyphenyl)-4-oxo-3,3a,4,6-tetra-hydro-1H-furo[3,4-c]pyran-3a-carboxylate

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Chemical Property of ethyl 3-(3,5-dimethoxyphenyl)-4-oxo-3,3a,4,6-tetra-hydro-1H-furo[3,4-c]pyran-3a-carboxylate

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Technology Process of ethyl 3-(3,5-dimethoxyphenyl)-4-oxo-3,3a,4,6-tetra-hydro-1H-furo[3,4-c]pyran-3a-carboxylate

There total 3 articles about ethyl 3-(3,5-dimethoxyphenyl)-4-oxo-3,3a,4,6-tetra-hydro-1H-furo[3,4-c]pyran-3a-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 628-23-9
butyne-1,4-diol

: 5859-67-6
diethyl 2-(3,5-dimethoxybenzylidene)malonate

: 1309359-45-2
ethyl 3-(3,5-dimethoxyphenyl)-4-oxo-3,3a,4,6-tetra-hydro-1H-furo[3,4-c]pyran-3a-carboxylate

Guidance literature:: butyne-1,4-diol; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.0833333h; Inert atmosphere;

diethyl 2-(3,5-dimethoxybenzylidene)malonate; With copper(l) iodide; In tetrahydrofuran; mineral oil; at 25 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.04.003

Reference yield: 51.0%

: 110-65-6
1,4-dihydroxybut-2-yne

: 5859-67-6
diethyl 2-(3,5-dimethoxybenzylidene)malonate

: 1309359-45-2
ethyl 3-(3,5-dimethoxyphenyl)-4-oxo-3,3a,4,6-tetra-hydro-1H-furo[3,4-c]pyran-3a-carboxylate

Guidance literature:: 1,4-dihydroxybut-2-yne; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.0833333h; Inert atmosphere;

diethyl 2-(3,5-dimethoxybenzylidene)malonate; With copper(l) iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 6h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; mineral oil; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2011.03.038

Reference yield: 23.0%

: 110-65-6
1,4-dihydroxybut-2-yne

: 5859-67-6
diethyl 2-(3,5-dimethoxybenzylidene)malonate

: 1309359-47-4
2-(3,5-dimethoxyphenyl)-4-vinyl-2,5-dihydrofuran-3-carboxylic acid

: 1309359-45-2
ethyl 3-(3,5-dimethoxyphenyl)-4-oxo-3,3a,4,6-tetra-hydro-1H-furo[3,4-c]pyran-3a-carboxylate

Guidance literature:: 1,4-dihydroxybut-2-yne; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.0833333h; Inert atmosphere;

diethyl 2-(3,5-dimethoxybenzylidene)malonate; With copper(l) iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 12h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; mineral oil; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2011.03.038