5859-67-6Relevant academic research and scientific papers
Synthesis and anti-tumor activity of novel ethyl 3-aryl-4-oxo-3,3a,4,6- tetrahydro-1H-furo[3,4-c]pyran-3a-carboxylates
Wang, Tiantian,Liu, Jia,Zhong, Hanyu,Chen, Huan,Lv, Zhiliang,Zhang, Yikai,Zhang, Mingfeng,Geng, Dongping,Niu, Chunjuan,Li, Yongmei,Li, Ke
, p. 3381 - 3383 (2011)
A series of ethyl 3-aryl-4-oxo-3,3a,4,6-tetrahydro-1H-furo[3,4-c]pyran-3a- carboxylates were prepared through the metal-catalyzed domino reaction of alkylidene malonates and 1,4-butynediol under a one-pot reaction condition at room temperature. Their in vitro anti-proliferative activities were subsequently evaluated in A549, QGY and HeLa cells. The majority of the compounds showed potent anti-tumor activity against HeLa cells. In particular, compound 3l was the most potent compound with IC50 value of 5.4 μM. For the first time, the X-ray structure of the anti-tumor ethyl 3-aryl-4-oxo-3,3a,4,6- tetrahydro-1H-furo[3,4-c]pyran-3a-carboxylates is determined.
Synthesis, chiral resolution, and determination of novel furan lignan derivatives with potent anti-tumor activity
Sun, Hai Ling,Wang, Tian Tian,Lv, Zhi Liang,Feng, Ji Lu,Geng, Dong Ping,Li, Yong Mei,Li, Ke
scheme or table, p. 1961 - 1964 (2010/09/18)
A kind of racemic furan lignans were synthesized via a novel route, and two optical isomers were obtained through a selective hydrolization. The absolute configurations were determined by circular dichroism spectroscopy after separated through a preparati
The construction of novel perylenequinone core via efficient synthesis of versatile ortho-naphthoquinone as a key intermediate
Kim, Beom-Tae,Kim, Ho-Seok,Moon, Woo Sung,Hwang, Ki-Jun
experimental part, p. 4625 - 4628 (2009/10/09)
The novel perylenequinone core, 1,12-diacetonitrile-3,10-perylenequinone, was successfully prepared from the dimerization of the key intermediate, 3-acetonitrile-1,2-naphthoquinone, which was synthesized by an efficient synthetic route in relatively short
