1-(2-Carboxy-1-methyl-2-oxo-ethyl)-4-hydroxy-cyclohexa-2,5-dienecarboxylic acid

Base Information

Chemical Name:1-(2-Carboxy-1-methyl-2-oxo-ethyl)-4-hydroxy-cyclohexa-2,5-dienecarboxylic acid
CAS No.:116130-27-9
Molecular Formula:C₁₁H₁₂O₆
Molecular Weight:240.213
Hs Code.:

Synonyms:1-(2-Carboxy-1-methyl-2-oxo-ethyl)-4-hydroxy-cyclohexa-2,5-dienecarboxylic acid

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Chemical Property of 1-(2-Carboxy-1-methyl-2-oxo-ethyl)-4-hydroxy-cyclohexa-2,5-dienecarboxylic acid

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Technology Process of 1-(2-Carboxy-1-methyl-2-oxo-ethyl)-4-hydroxy-cyclohexa-2,5-dienecarboxylic acid

There total 2 articles about 1-(2-Carboxy-1-methyl-2-oxo-ethyl)-4-hydroxy-cyclohexa-2,5-dienecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 116130-11-1
(+/-)-(Z)-9-methylchorismic acid

: 600-18-0
2-Oxobutyric acid

: 4658-69-9
α-keto-β-phenylbutyric acid

: 116130-27-9
1-(2-Carboxy-1-methyl-2-oxo-ethyl)-4-hydroxy-cyclohexa-2,5-dienecarboxylic acid

: 99-96-7
4-hydroxy-benzoic acid

Guidance literature:: In water-d2; at 30 ℃; Product distribution; Rate constant; uncatalysed and nish chorismate mutase catalyst;
DOI:10.1021/jo00256a016

Reference yield:

: 116130-11-1,116183-36-9,116257-37-5
(-)-9-methylchorismic acid

: 116130-27-9
1-((S)-2-Carboxy-1-methyl-2-oxo-ethyl)-4-hydroxy-cyclohexa-2,5-dienecarboxylic acid

Guidance literature:: With chorismate mutase-prephenate dehydrogenase (from E_. coli); In water; at 30 ℃; for 4h; Product distribution; Rate constant; Tris*HCl buffer, also uncatalysed reaction, D₂O;
DOI:10.1021/jo00256a016

Reference yield:

: 116130-27-9
1-((S)-2-Carboxy-1-methyl-2-oxo-ethyl)-4-hydroxy-cyclohexa-2,5-dienecarboxylic acid

: 68258-25-3
3-Phenyl-1,2-butanediol

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄ / 0.58 h

2: 1 N HCl / 1 h / 30 °C

3: diethyl ether

4: diisobutylaluminum hydride (DIBAH) / CH₂Cl₂; hexane; tetrahydrofuran

With hydrogenchloride; sodium tetrahydroborate; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jo00256a016