N^α-benzyloxycarbonyl-L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucine L-hemilanthionine α'-methyl ester hydrochloride

Base Information

• Chemical Name: N^α-benzyloxycarbonyl-L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucine L-hemilanthionine α'-methyl ester hydrochloride
• CAS No.: 75816-41-0
• Molecular Formula: C₃₀H₄₇N₅O₁₀S
• Molecular Weight: 669.797

Synonyms:N^α-benzyloxycarbonyl-L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucine L-hemilanthionine α'-methyl ester hydrochloride

Chemical Property of N^α-benzyloxycarbonyl-L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucine L-hemilanthionine α'-methyl ester hydrochloride

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N^α-benzyloxycarbonyl-L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucine L-hemilanthionine α'-methyl ester hydrochloride

There total 8 articles about N^α-benzyloxycarbonyl-L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucine L-hemilanthionine α'-methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

Nα-benzyloxycarbonyl-L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucine t-butyl ester L-hemilanthionine α'-methyl ester hydrochloride (75816-40-9) → Nα-benzyloxycarbonyl-L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucine L-hemilanthionine α'-methyl ester hydrochloride (75816-41-0)

Guidance literature:

With trifluoroacetic acid; for 0.666667h; Ambient temperature;

Reference yield:

Z-Ser-Leu-OBut (28252-48-4) → Nα-benzyloxycarbonyl-L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucine L-hemilanthionine α'-methyl ester hydrochloride (75816-41-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) hydrogen, 2.) 0.4N-hydrogen chloride / 1.) 10percent palladium-charcoal / 1.) 1percent acetic acid in methanol, 2.5 h, 2.) methanol, -15 deg C

2: 90 percent / triethylamine / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temperature, 1 h

3: 1.) hydrogen, 2.) 0.4N-hydrogene chloride in methanol / 1.) 10percent palladium-charcoal / 1.) 1percent acetic acid in methanol, 2.5 h, 2.) -15 deg C

4: 70 percent / triethylamine / dimethylformamide / 12 h / Ambient temperature

5: 96 percent / 1N hydrogen chloride in methanol / 0.5 h / Ambient temperature

6: 70 percent / 95percent trifluoroacetic acid / 0.67 h / Ambient temperature

With hydrogenchloride; hydrogen; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

N-Cbz-L-Isoleucine (3160-59-6) → Nα-benzyloxycarbonyl-L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucine L-hemilanthionine α'-methyl ester hydrochloride (75816-41-0)

Guidance literature:

Multi-step reaction with 6 steps

1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

2: 90 percent / triethylamine / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temperature, 1 h

3: 1.) hydrogen, 2.) 0.4N-hydrogene chloride in methanol / 1.) 10percent palladium-charcoal / 1.) 1percent acetic acid in methanol, 2.5 h, 2.) -15 deg C

4: 70 percent / triethylamine / dimethylformamide / 12 h / Ambient temperature

5: 96 percent / 1N hydrogen chloride in methanol / 0.5 h / Ambient temperature

6: 70 percent / 95percent trifluoroacetic acid / 0.67 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

N^α-benzyloxycarbonyl-L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucine t-butyl ester L-hemilanthionine α'-methyl ester hydrochloride

Z-Ser-Leu-OBu^t

N-Cbz-L-Isoleucine

Z-Ile-O-COOiBu

Downstream raw materials:

L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucyl-L-hemilanthionine α'-methyl ester picrate

N^α-benzyloxycarbonyl-L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucyl-L-hemilanthionine α'-methyl ester

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