(S)-2-P-TOLYLPIPERIDINE

Base Information

• Chemical Name: (S)-2-P-TOLYLPIPERIDINE
• CAS No.: 1228543-12-1
• Molecular Formula: C₁₂H₁₇N
• Molecular Weight: 175.274
• Mol file: 1228543-12-1.mol

Synonyms:2-(4-methylphenyl)-piperidine

Chemical Property of (S)-2-P-TOLYLPIPERIDINE

Chemical Property:

Purity/Quality:

99.00% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-P-TOLYLPIPERIDINE

There total 3 articles about (S)-2-P-TOLYLPIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(4-methylphenyl)-5-oxopentanoic acid (833-85-2) → 2-(4-methylphenyl)-piperidine (1228543-12-1)

Guidance literature:

With glucose dehydrogenase; D-glucose; pyridoxal 5'-phosphate; ω-transaminase ATA-113; Mycobacterium marinum carboxylic acid reductase; Streptomyces sp. GF₃₅₈₇ (R)-imine reductase; NAD; rac-Ala-OH; lactate dehydrogenase; In aq. phosphate buffer; at 30 ℃; for 24h; stereoselective reaction; Enzymatic reaction;

DOI:10.1021/acscatal.6b00855

Reference yield:

6-p-tolyl-2,3,4,5-tetrahydro-pyridine (105902-02-1) → 2-(4-methylphenyl)-piperidine (1228543-12-1) + 2-(4-methylphenyl)-piperidine (1228557-22-9)

Guidance literature:

With formic acid; C₃₄H₃₂ClN₂O₂RuS; triethylamine; In methanol; for 48h; optical yield given as %ee; enantioselective reaction;

DOI:10.1016/j.tetasy.2010.07.013

Reference yield:

6-p-tolyl-2,3,4,5-tetrahydro-pyridine (105902-02-1) → 2-(4-methylphenyl)-piperidine (1228543-12-1)

Guidance literature:

With (R)-imine reductase from Streptomyces sp GF₃₅₈₇; for 24h; enantioselective reaction;

DOI:10.1002/cctc.201402797

upstream raw materials:

6-p-tolyl-2,3,4,5-tetrahydro-pyridine

5-(4-methylphenyl)-5-oxopentanoic acid

Refernces

• 1、 France, Scott P.,Hussain, Shahed,Hill, Andrew M.,Hepworth, Lorna J.,Howard, Roger M.,Mulholland, Keith R.,Flitsch, Sabine L.,Turner, Nicholas J.. "One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts". . p. 3753 - 3759. Retrieved 2016/07/06.
• 2、 Martins, Jose E.D.,Contreras Redondo, Miguel A.,Wills, Martin. "Applications of N′-alkylated derivatives of TsDPEN in the asymmetric transfer hydrogenation of C=O and C=N bonds". experimental part. p. 2258 - 2264. Retrieved 2010/11/03.