p-nitrobenzyl <(4RS)-4-(2-t-butyldimethylsilyloxyethyl)-3-chloro-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxo-1-azetidin-1-yl>hydroxyacetate

Base Information

Chemical Name:p-nitrobenzyl <(4RS)-4-(2-t-butyldimethylsilyloxyethyl)-3-chloro-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxo-1-azetidin-1-yl>hydroxyacetate
CAS No.:133381-05-2
Molecular Formula:C₃₀H₃₈ClN₃O₁₂Si
Molecular Weight:696.183
Hs Code.:

p-nitrobenzyl <(4RS)-4-(2-t-butyldimethylsilyloxyethyl)-3-chloro-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxo-1-azetidin-1-yl>hydroxyacetate

Synonyms:p-nitrobenzyl <(4RS)-4-(2-t-butyldimethylsilyloxyethyl)-3-chloro-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxo-1-azetidin-1-yl>hydroxyacetate

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Chemical Property of p-nitrobenzyl <(4RS)-4-(2-t-butyldimethylsilyloxyethyl)-3-chloro-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxo-1-azetidin-1-yl>hydroxyacetate

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Technology Process of p-nitrobenzyl <(4RS)-4-(2-t-butyldimethylsilyloxyethyl)-3-chloro-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxo-1-azetidin-1-yl>hydroxyacetate

There total 6 articles about p-nitrobenzyl <(4RS)-4-(2-t-butyldimethylsilyloxyethyl)-3-chloro-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxo-1-azetidin-1-yl>hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 133381-04-1
p-nitrobenzyl <(4RS)-3-chloro-4-(2-hydroxyethyl)-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxoazetidin-1-yl>hydroxyacetate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 133381-05-2
p-nitrobenzyl <(4RS)-4-(2-t-butyldimethylsilyloxyethyl)-3-chloro-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxo-1-azetidin-1-yl>hydroxyacetate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 1.5h;

Reference yield:

: 73659-95-7,77003-49-7
(6RS,7SR)-7-acetyl-8-oxo-3-oxa-1-aza-bicyclo[4.2.0]octane-2-spirocyclohexane

: 133381-05-2
p-nitrobenzyl <(4RS)-4-(2-t-butyldimethylsilyloxyethyl)-3-chloro-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxo-1-azetidin-1-yl>hydroxyacetate

Guidance literature:: Multi-step reaction with 6 steps

1: 68 percent / chloramine-T / acetonitrile / 0.5 h / Ambient temperature

2: 91 percent / L-Selectride / tetrahydrofuran / 1 h / -70 °C

3: 1) lithium diisopropylamide / 1) THF, -70 deg C, 2) up to r.t.

4: 5 M sulphuric acid / 50 °C

5: 68 percent / benzene / 21 h / Heating

6: 48 percent / triethylamine / dimethylformamide / 1.5 h / 0 °C

With sulfuric acid; chloroamine-T; L-Selectride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; benzene;

Reference yield:

: 106673-95-4,106758-30-9,133443-86-4,142924-03-6
(6RS,9RS)-7-chloro-7-(1-hydroxyethyl)-8-oxo-3-oxa-1-azabicyclo<4.2.0>octane-2-spirocyclohexane

: 133381-05-2
p-nitrobenzyl <(4RS)-4-(2-t-butyldimethylsilyloxyethyl)-3-chloro-3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxo-1-azetidin-1-yl>hydroxyacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 1) lithium diisopropylamide / 1) THF, -70 deg C, 2) up to r.t.

2: 5 M sulphuric acid / 50 °C

3: 68 percent / benzene / 21 h / Heating

4: 48 percent / triethylamine / dimethylformamide / 1.5 h / 0 °C

With sulfuric acid; triethylamine; lithium diisopropyl amide; In N,N-dimethyl-formamide; benzene;