1-benzyl-4-<2-(N-methylcarbamoylamino)-5-chlorophenyl>-1,2,5,6-tetrahydropyridine

Base Information

• Chemical Name: 1-benzyl-4-<2-(N-methylcarbamoylamino)-5-chlorophenyl>-1,2,5,6-tetrahydropyridine
• CAS No.: 107191-02-6
• Molecular Formula: C₂₀H₂₂ClN₃O
• Molecular Weight: 355.867

Synonyms:1-benzyl-4-<2-(N-methylcarbamoylamino)-5-chlorophenyl>-1,2,5,6-tetrahydropyridine

Chemical Property of 1-benzyl-4-<2-(N-methylcarbamoylamino)-5-chlorophenyl>-1,2,5,6-tetrahydropyridine

Chemical Property:

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Technology Process of 1-benzyl-4-<2-(N-methylcarbamoylamino)-5-chlorophenyl>-1,2,5,6-tetrahydropyridine

There total 2 articles about 1-benzyl-4-<2-(N-methylcarbamoylamino)-5-chlorophenyl>-1,2,5,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.3%

4-(2-amino-5-chlorophenyl)-1-benzyl-1,2,5,6-tetrahydropyridine (107191-04-8) + methyl isocyanate (624-83-9) → 1-benzyl-4-<2-(N-methylcarbamoylamino)-5-chlorophenyl>-1,2,5,6-tetrahydropyridine (107191-02-6)

Guidance literature:

In ethyl acetate; at 50 ℃; for 2.5h;

DOI:10.1248/cpb.34.1901

Reference yield:

1-benzyl-4-hydroxy-4-(2-amino-5-chlorophenyl)piperidine (85732-70-3) → 1-benzyl-4-<2-(N-methylcarbamoylamino)-5-chlorophenyl>-1,2,5,6-tetrahydropyridine (107191-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 89.9 percent / H₂SO₄ / 3 h / Ambient temperature

2: 75.3 percent / ethyl acetate / 2.5 h / 50 °C

With sulfuric acid; In ethyl acetate;

DOI:10.1248/cpb.34.1901

Reference yield: 83.4%

1-benzyl-4-<2-(N-methylcarbamoylamino)-5-chlorophenyl>-1,2,5,6-tetrahydropyridine (107191-02-6) → 1-benzyl-6'-chloro-5,6-dihydro-3-iodo-3'-methyl-spiro-2'(1'H)-one (121061-01-6)

Guidance literature:

With iodine; sodium hydrogencarbonate; sodium iodide; In dichloromethane; water; for 2h; Ambient temperature;

upstream raw materials:

4-(2-amino-5-chlorophenyl)-1-benzyl-1,2,5,6-tetrahydropyridine

methyl isocyanate

1-benzyl-4-hydroxy-4-(2-amino-5-chlorophenyl)piperidine

Downstream raw materials:

2-benzyl-6-chloro-10-methylamino-1,2,3,4-tetrahydro-2,9-diazaphenanthrene

1'-benzyl-3'-bromo-6-chloro-2-methylamino-spiro<4H-3,1-benzoxazine-4,4'-piperidine>

1-benzyl-6'-chloro-5,6-dihydro-3-iodo-3'-methyl-spiro-2'(1'H)-one

1-benzyl-6'-chloro-3'-methyl-spiro-2'(1'H)-one

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