(1R)-tert-butoxy-1-methyl-2-oxoethyl (2R)-2-(4-methoxyanilino)pentanoate

Base Information

Chemical Name:(1R)-tert-butoxy-1-methyl-2-oxoethyl (2R)-2-(4-methoxyanilino)pentanoate
CAS No.:476689-71-1
Molecular Formula:C₁₉H₂₉NO₅
Molecular Weight:351.443
Hs Code.:

Synonyms:(1R)-tert-butoxy-1-methyl-2-oxoethyl (2R)-2-(4-methoxyanilino)pentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R)-tert-butoxy-1-methyl-2-oxoethyl (2R)-2-(4-methoxyanilino)pentanoate

Chemical Property:

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Technology Process of (1R)-tert-butoxy-1-methyl-2-oxoethyl (2R)-2-(4-methoxyanilino)pentanoate

There total 5 articles about (1R)-tert-butoxy-1-methyl-2-oxoethyl (2R)-2-(4-methoxyanilino)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68166-83-6
D-lactic acid t-butyl ester

: 476689-71-1
(1R)-tert-butoxy-1-methyl-2-oxoethyl (2R)-2-(4-methoxyanilino)pentanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 88 percent / Et₃N; DMAP / CH₂Cl₂ / 3 h / 0 - 20 °C

2.1: 100 percent / OsO₄; NaIO₄ / tetrahydrofuran; H₂O / 12 h / 20 °C

3.1: 100 percent / toluene / 0.5 h / Heating

4.1: MgCl₂; Me₂Zn / tetrahydrofuran / 0.33 h / -78 °C

4.2: tetrahydrofuran / 0.02 h / -78 °C

5.1: 92 percent / H₂ / 10percent Pd/C / ethanol / 6 h / 3040.2 Torr

With dmap; sodium periodate; osmium(VIII) oxide; hydrogen; dimethyl zinc(II); triethylamine; magnesium chloride; 10percent Pd/C; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1021/jo020327d

Reference yield:

: 104-94-9
4-methoxy-aniline

: 476689-71-1
(1R)-tert-butoxy-1-methyl-2-oxoethyl (2R)-2-(4-methoxyanilino)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / toluene / 0.5 h / Heating

2.1: MgCl₂; Me₂Zn / tetrahydrofuran / 0.33 h / -78 °C

2.2: tetrahydrofuran / 0.02 h / -78 °C

3.1: 92 percent / H₂ / 10percent Pd/C / ethanol / 6 h / 3040.2 Torr

With hydrogen; dimethyl zinc(II); magnesium chloride; 10percent Pd/C; In tetrahydrofuran; ethanol; toluene;
DOI:10.1021/jo020327d

Reference yield:

: 214278-70-3
tert-butyl-(2R)-2-[(oxoacetyl)oxy]propanoate

: 476689-71-1
(1R)-tert-butoxy-1-methyl-2-oxoethyl (2R)-2-(4-methoxyanilino)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / toluene / 0.5 h / Heating

2.1: MgCl₂; Me₂Zn / tetrahydrofuran / 0.33 h / -78 °C

2.2: tetrahydrofuran / 0.02 h / -78 °C

3.1: 92 percent / H₂ / 10percent Pd/C / ethanol / 6 h / 3040.2 Torr

With hydrogen; dimethyl zinc(II); magnesium chloride; 10percent Pd/C; In tetrahydrofuran; ethanol; toluene;
DOI:10.1021/jo020327d