3-(1'-cyanonona-1',8'-dien-5'-oxy)-5-(p-methoxyphenyl)-4-methylthiazole-2(3H)-thione

Base Information

Chemical Name:3-(1'-cyanonona-1',8'-dien-5'-oxy)-5-(p-methoxyphenyl)-4-methylthiazole-2(3H)-thione
CAS No.:1415260-84-2
Molecular Formula:C₂₁H₂₄N₂O₂S₂
Molecular Weight:400.566
Hs Code.:

Synonyms:3-(1'-cyanonona-1',8'-dien-5'-oxy)-5-(p-methoxyphenyl)-4-methylthiazole-2(3H)-thione

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Chemical Property of 3-(1'-cyanonona-1',8'-dien-5'-oxy)-5-(p-methoxyphenyl)-4-methylthiazole-2(3H)-thione

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Technology Process of 3-(1'-cyanonona-1',8'-dien-5'-oxy)-5-(p-methoxyphenyl)-4-methylthiazole-2(3H)-thione

There total 4 articles about 3-(1'-cyanonona-1',8'-dien-5'-oxy)-5-(p-methoxyphenyl)-4-methylthiazole-2(3H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415260-57-9
6-hydroxydeca-2,9-dienenitrile

: 529477-58-5
N-(hydroxy)-5-(p-methoxyphenyl)-4-methylthiazole-2(3H)-thione

: 1415260-84-2
3-(1'-cyanonona-1',8'-dien-5'-oxy)-5-(p-methoxyphenyl)-4-methylthiazole-2(3H)-thione

: 1415260-85-3
3-(1'-cyanonona-1',8'-dien-5'-oxy)-5-(p-methoxyphenyl)-4-methylthiazole-2(3H)-thione

Guidance literature:: With triphenylphosphine; In benzene; at 0 - 22 ℃; for 48h; Overall yield = 63 %; Overall yield = 1.53 mg; Optical yield = 42 %de; Inert atmosphere; Darkness;
DOI:10.1016/j.tet.2012.08.083

Reference yield:

: 90199-73-8
4-oxooct-7-enoic acid

: 1415260-84-2
3-(1'-cyanonona-1',8'-dien-5'-oxy)-5-(p-methoxyphenyl)-4-methylthiazole-2(3H)-thione

: 1415260-85-3
3-(1'-cyanonona-1',8'-dien-5'-oxy)-5-(p-methoxyphenyl)-4-methylthiazole-2(3H)-thione

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / ethanol / 2.5 h / 25 °C

2.1: diisobutylaluminium hydride / diethyl ether; dichloromethane / 0.25 h / -78 - 20 °C / Inert atmosphere

3.1: sodium hydroxide / dichloromethane / 0.02 h / 20 °C

3.2: 4 h / 60 °C / Inert atmosphere

4.1: triphenylphosphine / benzene / 48 h / 0 - 22 °C / Inert atmosphere; Darkness

With sodium tetrahydroborate; diisobutylaluminium hydride; triphenylphosphine; sodium hydroxide; In diethyl ether; ethanol; dichloromethane; benzene;
DOI:10.1016/j.tet.2012.08.083

Reference yield:

: 26524-72-1
5-(but-1’-en-4’-yl)dihydrofuran-2(3H)-one

: 1415260-84-2
3-(1'-cyanonona-1',8'-dien-5'-oxy)-5-(p-methoxyphenyl)-4-methylthiazole-2(3H)-thione

: 1415260-85-3
3-(1'-cyanonona-1',8'-dien-5'-oxy)-5-(p-methoxyphenyl)-4-methylthiazole-2(3H)-thione

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / diethyl ether; dichloromethane / 0.25 h / -78 - 20 °C / Inert atmosphere

2.1: sodium hydroxide / dichloromethane / 0.02 h / 20 °C

2.2: 4 h / 60 °C / Inert atmosphere

3.1: triphenylphosphine / benzene / 48 h / 0 - 22 °C / Inert atmosphere; Darkness

With diisobutylaluminium hydride; triphenylphosphine; sodium hydroxide; In diethyl ether; dichloromethane; benzene;
DOI:10.1016/j.tet.2012.08.083