4-(5-bromo-2-(4-phenethylthiazol-2-ylamino)pyridin-4-yl)-3-oxobutanoate

Base Information

Chemical Name:4-(5-bromo-2-(4-phenethylthiazol-2-ylamino)pyridin-4-yl)-3-oxobutanoate
CAS No.:945989-03-7
Molecular Formula:C₂₂H₂₂BrN₃O₃S
Molecular Weight:488.405
Hs Code.:

Synonyms:4-(5-bromo-2-(4-phenethylthiazol-2-ylamino)pyridin-4-yl)-3-oxobutanoate

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Chemical Property of 4-(5-bromo-2-(4-phenethylthiazol-2-ylamino)pyridin-4-yl)-3-oxobutanoate

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Technology Process of 4-(5-bromo-2-(4-phenethylthiazol-2-ylamino)pyridin-4-yl)-3-oxobutanoate

There total 7 articles about 4-(5-bromo-2-(4-phenethylthiazol-2-ylamino)pyridin-4-yl)-3-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.1%

: 945989-02-6
2-(5-bromo-2-(4-phenethylthiazol-2-ylamino)pyridin-4-yl)acetic acid

: 1071-46-1
hydrogen ethyl malonate

: 945989-03-7
4-(5-bromo-2-(4-phenethylthiazol-2-ylamino)pyridin-4-yl)-3-oxobutanoate

Guidance literature:: With isopropylmagnesium chloride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 - 50 ℃;

Reference yield:

: 937236-73-2
ethyl 2-(2-chloropyridin-4-yl)acetate

: 945989-03-7
4-(5-bromo-2-(4-phenethylthiazol-2-ylamino)pyridin-4-yl)-3-oxobutanoate

Guidance literature:: Multi-step reaction with 8 steps

1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 24 h / Heating / reflux

2: dichloromethane / 0 °C

3: bromine; acetic acid / 3 h

4: tetrahydrofuran / 20 °C

5: ethanol; potassium carbonate / 2 h / 70 °C

6: N-ethyl-N,N-diisopropylamine / ethanol / 2 h / 70 °C

7: sodium hydroxide; water / tetrahydrofuran / 2 h / 55 °C

8: isopropylmagnesium chloride; 1,1'-carbonyldiimidazole / tetrahydrofuran / 0 - 50 °C

With sodium hydroxide; ethanol; water; bromine; isopropylmagnesium chloride; potassium carbonate; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 945988-99-8
ethyl 2-(2-(3-benzoylthioureido)-5-bromopyridin-4-yl)acetate

: 945989-03-7
4-(5-bromo-2-(4-phenethylthiazol-2-ylamino)pyridin-4-yl)-3-oxobutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol; potassium carbonate / 2 h / 70 °C

2: N-ethyl-N,N-diisopropylamine / ethanol / 2 h / 70 °C

3: sodium hydroxide; water / tetrahydrofuran / 2 h / 55 °C

4: isopropylmagnesium chloride; 1,1'-carbonyldiimidazole / tetrahydrofuran / 0 - 50 °C

With sodium hydroxide; ethanol; water; isopropylmagnesium chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol;