N-ethyl-N-[2-(1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

Base Information

Chemical Name:N-ethyl-N-[2-(1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide
CAS No.:1420070-46-7
Molecular Formula:C₂₁H₂₀F₃N₃O
Molecular Weight:387.405
Hs Code.:

Synonyms:N-ethyl-N-[2-(1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

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Chemical Property of N-ethyl-N-[2-(1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

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Technology Process of N-ethyl-N-[2-(1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

There total 3 articles about N-ethyl-N-[2-(1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 272-49-1
1H-pyrrolo[3,2-b]pyridine

: 1219936-25-0
N-[2-bromo-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

: 1420070-46-7
N-ethyl-N-[2-(1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

Guidance literature:: With copper(l) iodide; cis-N,N'-dimethyl-1,2-diaminocyclohexane; In 1,4-dioxane; at 130 ℃; for 68h; Inert atmosphere;

Reference yield:

: 102684-91-3
2-bromo-5-(trifluoromethyl)benzaldehyde

: 1420070-46-7
N-ethyl-N-[2-(1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium cyanoborohydride; acetic acid / methanol; tetrahydrofuran / 20 °C

2: triethylamine / dichloromethane / 20 °C

3: potassium phosphate; copper(l) iodide; cis-N,N'-dimethyl-1,2-diaminocyclohexane / 1,4-dioxane / 20 h / 130 °C / Schlenk technique; Inert atmosphere

With potassium phosphate; copper(l) iodide; sodium cyanoborohydride; acetic acid; triethylamine; cis-N,N'-dimethyl-1,2-diaminocyclohexane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 1175526-32-5
N-[2-bromo-5-(trifluoromethyl)benzyl]ethanamine

: 1420070-46-7
N-ethyl-N-[2-(1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C

2: potassium phosphate; copper(l) iodide; cis-N,N'-dimethyl-1,2-diaminocyclohexane / 1,4-dioxane / 20 h / 130 °C / Schlenk technique; Inert atmosphere

With potassium phosphate; copper(l) iodide; triethylamine; cis-N,N'-dimethyl-1,2-diaminocyclohexane; In 1,4-dioxane; dichloromethane;