tert-butyl {1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}acetate

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Chemical Name:tert-butyl {1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}acetate
CAS No.:1420070-48-9
Molecular Formula:C₂₇H₃₀F₃N₃O₃
Molecular Weight:501.549
Hs Code.:

Synonyms:tert-butyl {1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}acetate

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Chemical Property of tert-butyl {1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}acetate

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Technology Process of tert-butyl {1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}acetate

There total 5 articles about tert-butyl {1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 321745-86-2
2-tert-butoxy-2-oxoethylzinc chloride

: 1420070-47-8
N-[2-(3-bromo-1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]-N-ethylcyclopropanecarboxamide

: 1420070-48-9
tert-butyl {1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}acetate

Guidance literature:: With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; at 100 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1420070-46-7
N-ethyl-N-[2-(1H-pyrrolo[2,3-b]pyridin-1-yl)-5-(trifluoromethyl)benzyl]cyclopropanecarboxamide

: 1420070-48-9
tert-butyl {1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / ethyl acetate / 1.5 h / 20 °C

2: monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / tetrahydrofuran; diethyl ether / 1 h / 100 °C / Inert atmosphere; Microwave irradiation

With N-Bromosuccinimide; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; ethyl acetate;

Reference yield:

: 102684-91-3
2-bromo-5-(trifluoromethyl)benzaldehyde

: 1420070-48-9
tert-butyl {1-[2-{[(cyclopropylcarbonyl)(ethyl)amino]methyl}-4-(trifluoromethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}acetate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium cyanoborohydride; acetic acid / methanol; tetrahydrofuran / 20 °C

2: triethylamine / dichloromethane / 20 °C

3: potassium phosphate; copper(l) iodide; cis-N,N'-dimethyl-1,2-diaminocyclohexane / 1,4-dioxane / 20 h / 130 °C / Schlenk technique; Inert atmosphere

4: N-Bromosuccinimide / ethyl acetate / 1.5 h / 20 °C

5: monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / tetrahydrofuran; diethyl ether / 1 h / 100 °C / Inert atmosphere; Microwave irradiation

With potassium phosphate; N-Bromosuccinimide; copper(l) iodide; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; sodium cyanoborohydride; acetic acid; triethylamine; cis-N,N'-dimethyl-1,2-diaminocyclohexane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; ethyl acetate;