2-chloro-N-(3-isopropoxypropyl)acetamide

Base Information

• Chemical Name: 2-chloro-N-(3-isopropoxypropyl)acetamide
• CAS No.: 10263-67-9
• Molecular Formula: C8H16ClNO2
• Molecular Weight: 0
• Hs Code.: 2924199090
• NSC Number: 8279
• DSSTox Substance ID: DTXSID00278580
• Wikidata: Q82010565
• Mol file: 10263-67-9.mol

Synonyms:10263-67-9;2-chloro-N-(3-isopropoxypropyl)acetamide;2-chloro-N-(3-propan-2-yloxypropyl)acetamide;2-chloro-n-[3-(propan-2-yloxy)propyl]acetamide;Acetamide, 2-chloro-N-[3-(1-methylethoxy)propyl]-;NSC8279;DTXSID00278580;NSC 8279;NSC-8279;AKOS009075990;CS-0241579;EN300-23442;Z147647998

Chemical Property of 2-chloro-N-(3-isopropoxypropyl)acetamide

Chemical Property:

• Vapor Pressure: 0.000323mmHg at 25°C
• Boiling Point: 320.2°Cat760mmHg
• Flash Point: 147.4°C
• PSA: 38.33000
• Density: 1.048g/cm³
• LogP: 1.54740
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 193.0869564
• Heavy Atom Count: 12
• Complexity: 128

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-CHLORO-N-(3-ISOPROPOXYPROPYL)ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)OCCCNC(=O)CCl

Technology Process of 2-chloro-N-(3-isopropoxypropyl)acetamide

There total 1 articles about 2-chloro-N-(3-isopropoxypropyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloroacetyl chloride (79-04-9) + 3-Isopropoxy-propylamin (2906-12-9) → chloro-acetic acid-(3-isopropoxy-propylamide) (10263-67-9)

Guidance literature:

With sodium hydroxide; 1,2-dichloro-ethane;

DOI:10.1021/ja01592a061

Reference yield: 92.0%

chloro-acetic acid-(3-isopropoxy-propylamide) (10263-67-9) + 1-Chloro-3-chloromethyl-benzene (620-20-2,130468-19-8) → (814)T7232

Guidance literature:

1-Chloro-3-chloromethyl-benzene; With thiourea; In isopropyl alcohol; at 100 ℃; for 2h; Sealed tube;

chloro-acetic acid-(3-isopropoxy-propylamide); With potassium hydroxide; In methanol; isopropyl alcohol; at 60 ℃; for 2h; Sonication;

DOI:10.1021/acscombsci.5b00024

Reference yield:

chloro-acetic acid-(3-isopropoxy-propylamide) (10263-67-9) → (414)T7101

Guidance literature:

Multi-step reaction with 2 steps

1.1: thiourea / isopropyl alcohol / 2 h / 100 °C / Sealed tube

1.2: 2 h / 60 °C / Sonication

2.1: acetic acid; dihydrogen peroxide / methanol; water / 4 h / 40 °C / Sonication

With dihydrogen peroxide; acetic acid; thiourea; In methanol; water; isopropyl alcohol;

DOI:10.1021/acscombsci.5b00024

upstream raw materials:

chloroacetyl chloride

3-Isopropoxy-propylamin