N-(3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]pyrimidin-2-ylamino}phenyl)acrylamide

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Chemical Name:N-(3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]pyrimidin-2-ylamino}phenyl)acrylamide
CAS No.:1453199-00-2
Molecular Formula:C₂₇H₂₀ClN₅O₃S
Molecular Weight:530.006
Hs Code.:

Synonyms:N-(3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]pyrimidin-2-ylamino}phenyl)acrylamide

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Chemical Property of N-(3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]pyrimidin-2-ylamino}phenyl)acrylamide

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Technology Process of N-(3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]pyrimidin-2-ylamino}phenyl)acrylamide

There total 4 articles about N-(3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]pyrimidin-2-ylamino}phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1453198-99-6
N₁-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]pyrimidin-2-yl}-benzene-1,3-diamine

: 814-68-6,25189-84-8
acryloyl chloride

: 1453199-00-2
N-(3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]pyrimidin-2-ylamino}phenyl)acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm400822z

Reference yield:

: 882562-40-5
3-(2,5-dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole

: 1453199-00-2
N-(3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]pyrimidin-2-ylamino}phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 80 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm400822z

Reference yield:

: 870717-93-4
1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole

: 1453199-00-2
N-(3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]pyrimidin-2-ylamino}phenyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / Inert atmosphere; Reflux

2: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 80 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;
DOI:10.1021/jm400822z