882562-40-5

Basic information

• Product Name: 1-(benzenesulfonyl)-3-(2,5-dichloropyriMidin-4-yl)-1H-indole
• Synonyms: 1-(benzenesulfonyl)-3-(2,5-dichloropyriMidin-4-yl)-1H-indole;3-(2,5-dichloropyriMidin-4-yl)-1-(phenylsulfonyl)-1H-indole
• CAS NO: 882562-40-5
• Molecular Formula: C₁₈H₁₁Cl₂N₃O₂S
• Molecular Weight: 404.26984
• Mol File: 882562-40-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 650.4±65.0 °C(Predicted)
• Appearance: /
• Density: 1.51±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.21±0.40(Predicted)
• CAS DataBase Reference: 1-(benzenesulfonyl)-3-(2,5-dichloropyriMidin-4-yl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(benzenesulfonyl)-3-(2,5-dichloropyriMidin-4-yl)-1H-indole(882562-40-5)
• EPA Substance Registry System: 1-(benzenesulfonyl)-3-(2,5-dichloropyriMidin-4-yl)-1H-indole(882562-40-5)

Safety Data

• Hazardous Substances Data: 882562-40-5(Hazardous Substances Data)

Usage

Uses

3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole can be used to synthesize CDK or JNK inhibitors.

Upstream product

• 870717-93-4 1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 
• 5750-76-5 2,4,5-trichloropyrimidine 
• 120-72-9 indole 
• 937366-57-9 3-(2,5-dichloropyrimidine-4-yl)-1H-indole 
• 98-09-9 benzenesulfonyl chloride 
• 129271-98-3 1-(phenylsulfonyl)-1H-indol-3-ylboronic acid 

Downstream Products

• 937366-57-9 3-(2,5-dichloropyrimidine-4-yl)-1H-indole 
• 1421372-00-0 4-[1-(benzenesulfonyl)indol-3-yl]-5-chloro-N-[2-methoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitrophenyl]pyrimidin-2-amine 
• 1421371-98-3 4-methoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-N'-{5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl}benzene-1,3-diamine 
• 1421371-99-4 N'-{4-[1-(benzenesulfonyl)indol-3-yl]-5-chloropyrimidin-2-yl}-4-methoxy-6-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)benzene-1,3-diamine 
• 1421373-39-8 C₂₈H₂₇ClN₆O₂ 
• 1453199-31-9 (E)-N-(3-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(dimethylamino)but-2-enamide 
• 1453199-32-0 (E)-N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(dimethylamino)but-2-enamide 
• 1453198-99-6 N₁-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]pyrimidin-2-yl}-benzene-1,3-diamine 
• 1453199-00-2 N-(3-{5-chloro-4-[1-(phenylsulfonyl)-1H-indol-3-yl]pyrimidin-2-ylamino}phenyl)acrylamide 
• 1453199-01-3 N-{3-[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino]phenyl}acrylamide 
• 1453199-03-5 N₁-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,4-diamine 
• 1453199-04-6 N-(4-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide 
• 1453199-05-7 N-(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide 
• 1453199-09-1 N-(5-chloro-4-(1-(phenylsulfonyl)-1H-indol-3-yl)pyrimidin-2-yl)-5-methoxyindolin-6-amine 

Relevant articles and documents

CDK inhibitor based on organic arsine as well as preparation method and application of CDK inhibitor

The invention provides a CDK inhibitor based on organic arsine as well as a preparation method and application of the CDK inhibitor. Specifically, the invention providese compounds of Formula I, or stereoisomers or tautomers thereof, or pharmaceutically acceptable salts, hydrates or solvates thereof; and the invention also discloses a preparation method and application thereof. Definitions of allgroups in the formula are shown in the specification.

AMINOPYRIMIDINE COMPOUNDS

Disclosed herein are aminopyrimidine compounds that inhibit FGFR and methods of treating diseases and/or conditions (e.g., cancer) with the aminopyrimidine compounds disclosed herein.

Pyrimidine amine compound, and preparation method and application thereof

The invention discloses a polycyclic compound, and a preparation method and an application thereof. The invention provides the polycyclic compound represented by formula I, or a pharmaceutically acceptable salt thereof. The compound has a relatively good inhibition effect on CDK7.