Technology Process of (1R,2R,3R)-3-(3-(benzyloxy)benzyl)-2-((3S,1E)-3-hydroxyoct-1-enyl)-4-methylenecyclopentanol
There total 5 articles about (1R,2R,3R)-3-(3-(benzyloxy)benzyl)-2-((3S,1E)-3-hydroxyoct-1-enyl)-4-methylenecyclopentanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
water; acetone;
at 25 ℃;
for 1h;
- Guidance literature:
-
(2R,3R,4R)-2-(3-(benzyloxy)benzyl)-4-triethylsilyloxy-3-((3S,1E)-3-triethylsilyloxyoct-1-enyl)cyclopentanone; 1,1-dibromomethane;
With
toluene-4-sulfonic acid;
In
tetrahydrofuran; dichloromethane;
at 25 ℃;
for 1.5h;
Cooling with ice;
With
toluene-4-sulfonic acid;
In
water; acetone;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium; copper(l) cyanide; methyllithium / diethyl ether; hexane; tetrahydrofuran / 0.5 h / -70 °C
1.2: 0.5 h / -70 °C
2.1: toluene-4-sulfonic acid / tetrahydrofuran; dichloromethane / 1.5 h / 25 °C / Cooling with ice
2.2: 1 h / 20 °C
With
n-butyllithium; methyllithium; copper(l) cyanide; toluene-4-sulfonic acid;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane;