2-methyl-2-(4-(9-oxo-2-(quinolin-3-yl)pyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl) propanenitrile

Base Information

Chemical Name:2-methyl-2-(4-(9-oxo-2-(quinolin-3-yl)pyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl) propanenitrile
CAS No.:1415999-80-2
Molecular Formula:C₃₀H₂₁N₅O
Molecular Weight:467.53
Hs Code.:

Synonyms:2-methyl-2-(4-(9-oxo-2-(quinolin-3-yl)pyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl) propanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methyl-2-(4-(9-oxo-2-(quinolin-3-yl)pyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl) propanenitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-methyl-2-(4-(9-oxo-2-(quinolin-3-yl)pyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl) propanenitrile

There total 9 articles about 2-methyl-2-(4-(9-oxo-2-(quinolin-3-yl)pyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl) propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.9%

: 14221-01-3
tetrakis(triphenylphosphine) palladium⁽⁰⁾

: 1415999-80-2
2-methyl-2-(4-(9-oxo-2-(quinolin-3-yl)pyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl) propanenitrile

Guidance literature:: With sodium carbonate; In dichloromethane;

Reference yield: 27.9%

: 1416000-76-4
2-(4-(2-chloro-9-oxopyrido[3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl)-2-methyl propanenitrile

: 191162-39-7
quinolin-3-ylboronic acid

: 1415999-80-2
2-methyl-2-(4-(9-oxo-2-(quinolin-3-yl)pyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl) propanenitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; for 8h; Inert atmosphere; Reflux;

Reference yield:

: 127094-57-9
4,6-dichloro-(1,5)-naphthyridine-3-carboxylic acid ethyl ester

: 1415999-80-2
2-methyl-2-(4-(9-oxo-2-(quinolin-3-yl)pyrido [3,2-c][1,5]naphthyridin-10(9H)-yl)phenyl) propanenitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 1,4-dioxane / 4 h / Reflux

2: sodium tetrahydroborate; ethanol / 24 h / 20 °C

3: manganese(IV) oxide / dichloromethane / 30 h / 20 °C

4: potassium carbonate / tert-butyl alcohol / 48 h / 160 °C / Sealed tube

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 8 h / Inert atmosphere; Reflux

With manganese(IV) oxide; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanol; sodium carbonate; potassium carbonate; In 1,4-dioxane; ethanol; dichloromethane; toluene; tert-butyl alcohol;