7-(7-(2-hydroxypropan-2-yl)-6-oxo-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

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Chemical Name:7-(7-(2-hydroxypropan-2-yl)-6-oxo-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid
CAS No.:1447304-74-6
Molecular Formula:C₃₁H₃₇N₃O₄
Molecular Weight:515.652
Hs Code.:

Synonyms:7-(7-(2-hydroxypropan-2-yl)-6-oxo-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

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Chemical Property of 7-(7-(2-hydroxypropan-2-yl)-6-oxo-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

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Technology Process of 7-(7-(2-hydroxypropan-2-yl)-6-oxo-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

There total 4 articles about 7-(7-(2-hydroxypropan-2-yl)-6-oxo-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356332-15-4
7‐[2,3‐bis(4‐methylphenyl)‐6‐oxo‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐5‐yl]heptanoic acid

: 67-64-1
acetone

: 1447304-74-6
7-(7-(2-hydroxypropan-2-yl)-6-oxo-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Guidance literature:: 7‐[2,3‐bis(4‐methylphenyl)‐6‐oxo‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐5‐yl]heptanoic acid; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

acetone; In tetrahydrofuran; at -65 ℃;

Reference yield:

: 29823-18-5
ethyl 7-bromoheptanoate

: 1447304-74-6
7-(7-(2-hydroxypropan-2-yl)-6-oxo-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 23 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide; methanol / 1 h / 50 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

3.2: -65 °C

With methanol; potassium carbonate; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1356333-20-4
ethyl 7‐[2,3‐bis(4‐methylphenyl)‐6‐oxo‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐5‐yl]heptanoate

: 1447304-74-6
7-(7-(2-hydroxypropan-2-yl)-6-oxo-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; methanol / 1 h / 50 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

2.2: -65 °C

With methanol; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran;