N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

Base Information

• Chemical Name: N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide
• CAS No.: 1240515-89-2
• Molecular Formula: C₂₂H₂₁ClN₄O₄S₂
• Molecular Weight: 505.018
• Mol file: 1240515-89-2.mol

Synonyms:N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

Chemical Property of N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide

There total 13 articles about N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-[1-{[3-(aminomethyl)phenyl]methyl}-4-methyloxy-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide hydrochloride (1240518-04-0) + acetic anhydride (108-24-7) → N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide (1240515-89-2)

Guidance literature:

N-[1-{[3-(aminomethyl)phenyl]methyl}-4-methyloxy-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide hydrochloride; With triethylamine; In dichloromethane; at 20 ℃; for 0.333333h;

acetic anhydride; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jm301572h

Reference yield:

C26H22Cl2N4O6S4 → N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide (1240515-89-2)

Guidance literature:

With water; sodium hydroxide; In methanol; at 50 ℃;

DOI:10.1016/j.bmcl.2012.02.104

Reference yield:

4-(methyloxy)-1H-indazol-3-amine (886362-07-8) → N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide (1240515-89-2)

Guidance literature:

Multi-step reaction with 6 steps

1: dmap; triethylamine / dichloromethane

2: pyridine / dichloromethane

3: N-ethyl-N,N-diisopropylamine / dichloromethane

4: water; sodium carbonate / N,N-dimethyl-formamide / 85 °C

5: potassium carbonate / N,N-dimethyl-formamide

6: tetrabutyl ammonium fluoride / tetrahydrofuran

With pyridine; dmap; tetrabutyl ammonium fluoride; water; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.02.104

upstream raw materials:

N-[1-{[3-(aminomethyl)phenyl]methyl}-4-methyloxy-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide hydrochloride

acetic anhydride

4-(methyloxy)-1H-indazol-3-amine

1,1-dimethylethyl 3-amino-4-(methyloxy)-1H-indazole-1-carboxylate

Downstream raw materials:

N-{[3-({4-(Methyloxy)-3-[(2-thienylsulfonyl)amino]-1H-indazol-1-yl}methyl)phenyl]methyl}acetamide