N-[1-{[3-(aminomethyl)phenyl]methyl}-4-methyloxy-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide hydrochloride

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Chemical Name:N-[1-{[3-(aminomethyl)phenyl]methyl}-4-methyloxy-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide hydrochloride
CAS No.:1240518-04-0
Molecular Formula:C₂₀H₁₉ClN₄O₃S₂*ClH
Molecular Weight:499.442
Hs Code.:
Mol file:1240518-04-0.mol

Synonyms:N-[1-{[3-(aminomethyl)phenyl]methyl}-4-methyloxy-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide hydrochloride

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Chemical Property of N-[1-{[3-(aminomethyl)phenyl]methyl}-4-methyloxy-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide hydrochloride Edit

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Technology Process of N-[1-{[3-(aminomethyl)phenyl]methyl}-4-methyloxy-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide hydrochloride

There total 4 articles about N-[1-{[3-(aminomethyl)phenyl]methyl}-4-methyloxy-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1240518-03-9
5-chloro-N-{1-[(3-cyanophenyl)methyl]-4-(methoxy)-1H-indazole-3-yl}-2-thiophene sulphonamide

: 1240518-04-0
N-[1-{[3-(aminomethyl)phenyl]methyl}-4-methyloxy-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide hydrochloride

Guidance literature:: 5-chloro-N-{1-[(3-cyanophenyl)methyl]-4-(methoxy)-1H-indazole-3-yl}-2-thiophene sulphonamide; With lithium aluminium tetrahydride; In tetrahydrofuran; at 10 - 20 ℃;

With water; sodium hydroxide; In tetrahydrofuran; for 0.5h;

With hydrogenchloride; In methanol; water;

Reference yield:

: 94088-46-7
2-fluoro-6-methoxybenzonitrile

: 1240518-04-0
N-[1-{[3-(aminomethyl)phenyl]methyl}-4-methyloxy-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / butan-1-ol / 18 h / Reflux; Inert atmosphere

2.1: potassium hydroxide / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

2.2: 0.33 h / Inert atmosphere

3.1: pyridine / 0.67 h / 20 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1 h / 10 - 20 °C

4.2: 0.5 h

With pyridine; lithium aluminium tetrahydride; hydrazine hydrate; potassium hydroxide; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; butan-1-ol;

Reference yield:

: 886362-07-8
4-(methyloxy)-1H-indazol-3-amine

: 1240518-04-0
N-[1-{[3-(aminomethyl)phenyl]methyl}-4-methyloxy-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere

1.2: 0.33 h / Inert atmosphere

2.1: pyridine / 0.67 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1 h / 10 - 20 °C

3.2: 0.5 h

With pyridine; lithium aluminium tetrahydride; potassium hydroxide; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;