Methyl 2-(5-(4-bromophenyl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butyrate

Base Information

Chemical Name:Methyl 2-(5-(4-bromophenyl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butyrate
CAS No.:1170193-16-4
Molecular Formula:C₁₆H₁₆BrNO₄S₂
Molecular Weight:430.343
Hs Code.:

Synonyms:Methyl 2-(5-(4-bromophenyl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butyrate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 2-(5-(4-bromophenyl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butyrate

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Technology Process of Methyl 2-(5-(4-bromophenyl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butyrate

There total 3 articles about Methyl 2-(5-(4-bromophenyl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 623-42-7
butanoic acid methyl ester

: 1428510-57-9
C₁₁H₈BrNO₂S₂

: 1170193-16-4
Methyl 2-(5-(4-bromophenyl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butyrate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃;
DOI:10.1016/j.bmcl.2013.01.120

Reference yield:

: 91076-95-8
methyl 3-amino-5-(4’-bromophenyl)thiophene-2-carboxylate

: 1170193-16-4
Methyl 2-(5-(4-bromophenyl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butyrate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium nitrate; sulfur dioxide; hydrogenchloride / water

1.2: 0 °C

2.1: ammonia / 1,4-dioxane / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

4.1: triphenylphosphine; carbon tetrabromide / tetrahydrofuran; dichloromethane / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 55 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 60 °C

With hydrogenchloride; sodium nitrate; lithium aluminium tetrahydride; carbon tetrabromide; sulfur dioxide; ammonia; sodium hydride; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.01.120

Reference yield:

: 1428510-55-7
C₁₁H₁₀BrNO₃S₂

: 1170193-16-4
Methyl 2-(5-(4-bromophenyl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butyrate

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; carbon tetrabromide / tetrahydrofuran; dichloromethane / 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 55 °C

3: sodium hydride / N,N-dimethyl-formamide / 60 °C

With carbon tetrabromide; sodium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.01.120