2-(5-(biphenyl-4-yl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butanoic acid

Base Information

Chemical Name:2-(5-(biphenyl-4-yl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butanoic acid
CAS No.:1170193-68-6
Molecular Formula:C₂₁H₁₉NO₄S₂
Molecular Weight:413.518
Hs Code.:

Synonyms:2-(5-(biphenyl-4-yl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butanoic acid

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Chemical Property of 2-(5-(biphenyl-4-yl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butanoic acid

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Technology Process of 2-(5-(biphenyl-4-yl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butanoic acid

There total 5 articles about 2-(5-(biphenyl-4-yl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1170193-16-4
Methyl 2-(5-(4-bromophenyl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butyrate

: 98-80-6
phenylboronic acid

: 1170193-68-6
2-(5-(biphenyl-4-yl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butanoic acid

Guidance literature:: Methyl 2-(5-(4-bromophenyl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butyrate; phenylboronic acid; With water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 100 ℃; for 48h;

With hydrogenchloride; In 1,2-dimethoxyethane; water; ethyl acetate;

Reference yield:

: 1435099-96-9
C₂₂H₂₁NO₄S₂

: 1170193-68-6
2-(5-(biphenyl-4-yl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butanoic acid

Guidance literature:: With sodium hydroxide; In methanol; water; at 20 ℃;
DOI:10.1016/j.bmcl.2013.01.120

Reference yield:

: 1375472-72-2
C₁₂H₈BrClO₄S₂

: 1170193-68-6
2-(5-(biphenyl-4-yl)-1,1-dioxothieno[2,3-d]isothiazol-2(3H)-yl)butanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: ammonia / 1,4-dioxane / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

3: triphenylphosphine; carbon tetrabromide / tetrahydrofuran; dichloromethane / 20 °C

4: sodium hydride / N,N-dimethyl-formamide / 55 °C

5: sodium hydride / N,N-dimethyl-formamide / 60 °C

6: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris-(o-tolyl)phosphine; potassium phosphate / 140 °C / Microwave irradiation

7: sodium hydroxide / water; methanol / 20 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; carbon tetrabromide; ammonia; sodium hydride; triphenylphosphine; tris-(o-tolyl)phosphine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; 6: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2013.01.120