methyl 4-(2-{5-chloro-1-(diphenylmethyl)-2-[(E)-2-methoxyvinyl]-1H-indol-3-yl}ethoxy)benzoate

Base Information

• Chemical Name: methyl 4-(2-{5-chloro-1-(diphenylmethyl)-2-[(E)-2-methoxyvinyl]-1H-indol-3-yl}ethoxy)benzoate
• CAS No.: 934285-18-4
• Molecular Formula: C₃₄H₃₀ClNO₄
• Molecular Weight: 552.07
• Mol file: 934285-18-4.mol

Synonyms:methyl 4-(2-{5-chloro-1-(diphenylmethyl)-2-[(E)-2-methoxyvinyl]-1H-indol-3-yl}ethoxy)benzoate

Chemical Property of methyl 4-(2-{5-chloro-1-(diphenylmethyl)-2-[(E)-2-methoxyvinyl]-1H-indol-3-yl}ethoxy)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(2-{5-chloro-1-(diphenylmethyl)-2-[(E)-2-methoxyvinyl]-1H-indol-3-yl}ethoxy)benzoate

There total 3 articles about methyl 4-(2-{5-chloro-1-(diphenylmethyl)-2-[(E)-2-methoxyvinyl]-1H-indol-3-yl}ethoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

methyl 4-{2-[5-chloro-1-(diphenylmethyl)-2-formyl-1H-indol-3-yl]ethoxy}benzoate (479422-26-9) + (methoxymethyl)triphenylphosphonium chloride (4009-98-7) → methyl 4-(2-{5-chloro-1-(diphenylmethyl)-2-[(E)-2-methoxyvinyl]-1H-indol-3-yl}ethoxy)benzoate (934285-18-4)

Guidance literature:

(methoxymethyl)triphenylphosphonium chloride; With potassium hexamethylsilazane; In tetrahydrofuran; at 0 ℃; for 0.166667h;

methyl 4-{2-[5-chloro-1-(diphenylmethyl)-2-formyl-1H-indol-3-yl]ethoxy}benzoate; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Further stages.;

DOI:10.1021/jm061131z

Reference yield:

methyl 4-[2-[5-chloro-(1-diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]benzoate (479422-24-7) → methyl 4-(2-{5-chloro-1-(diphenylmethyl)-2-[(E)-2-methoxyvinyl]-1H-indol-3-yl}ethoxy)benzoate (934285-18-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NBS; benzoyl peroxide / CCl₄ / 2.5 h / Heating

2.1: 0.750 g / Ag₂CO₃; H₂O / acetone

3.1: KHMDS / tetrahydrofuran / 0.17 h / 0 °C

3.2: 40 percent / tetrahydrofuran / 3 h / 0 - 20 °C

With N-Bromosuccinimide; water; potassium hexamethylsilazane; silver carbonate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; acetone;

DOI:10.1021/jm061131z

Reference yield:

C32H26Br2ClNO3 (683813-75-4) → methyl 4-(2-{5-chloro-1-(diphenylmethyl)-2-[(E)-2-methoxyvinyl]-1H-indol-3-yl}ethoxy)benzoate (934285-18-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 0.750 g / Ag₂CO₃; H₂O / acetone

2.1: KHMDS / tetrahydrofuran / 0.17 h / 0 °C

2.2: 40 percent / tetrahydrofuran / 3 h / 0 - 20 °C

With water; potassium hexamethylsilazane; silver carbonate; In tetrahydrofuran; acetone;

DOI:10.1021/jm061131z

upstream raw materials:

methyl 4-{2-[5-chloro-1-(diphenylmethyl)-2-formyl-1H-indol-3-yl]ethoxy}benzoate

(methoxymethyl)triphenylphosphonium chloride

methyl 4-[2-[5-chloro-(1-diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]benzoate

C₃₂H₂₆Br₂ClNO₃

Downstream raw materials:

methyl 4-{2-[5-chloro-1-(diphenylmethyl)-2-(2-oxoethyl)-1H-indol-3-yl]ethoxy}benzoate