[(1S,2R,3S)-3-(6-amino-9H-purin-9-yl)-2-fluorocyclopentyl]methanol

Base Information

Chemical Name:[(1S,2R,3S)-3-(6-amino-9H-purin-9-yl)-2-fluorocyclopentyl]methanol
CAS No.:129746-12-9
Molecular Formula:C₁₁H₁₄FN₅O
Molecular Weight:251.263
Hs Code.:

Synonyms:Cyclopentanemethanol,3-(6-amino-9H-purin-9-yl)-2-fluoro-, (1a,2a,3a)- (9CI); Cyclopentanemethanol,3-(6-amino-9H-purin-9-yl)-2-fluoro-, (1a,2a,3a)-(?à)-

Suppliers and Price of [(1S,2R,3S)-3-(6-amino-9H-purin-9-yl)-2-fluorocyclopentyl]methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of [(1S,2R,3S)-3-(6-amino-9H-purin-9-yl)-2-fluorocyclopentyl]methanol

Chemical Property:

Vapor Pressure:2.06E-11mmHg at 25°C
Boiling Point:514.5°C at 760 mmHg
Flash Point:265°C
Density:1.71g/cm³

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of [(1S,2R,3S)-3-(6-amino-9H-purin-9-yl)-2-fluorocyclopentyl]methanol

There total 19 articles about [(1S,2R,3S)-3-(6-amino-9H-purin-9-yl)-2-fluorocyclopentyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119895-90-8
triphenylmethoxymethylcyclopent-2-ene

: 129746-12-9,129829-88-5
[(1R,2R,3R)-3-(6-Amino-purin-9-yl)-2-fluoro-cyclopentyl]-methanol

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) dimethyldibromohydantoin, 2.) K₂CO₃ / 1.) H₂O, acetone, 0 deg C, 2.) MeOH

2: 84 percent / NaN₃, NH₄Cl / ethanol; H₂O / 90 °C

3: diethylaminosulphur trifluoride (DAST) / CH₂Cl₂ / 0 °C

4: H₂ / Lindlar catalyst / ethanol

5: Et₃N / CH₂Cl₂ / Ambient temperature

6: H₂ / Raney Ni / dioxane

7: H⁺

8: NH₃(l) / 18 h / Ambient temperature

9: aq. HCl / 0.08 h

With hydrogenchloride; sodium azide; dimethyldibromohydantoin; diethylamino-sulfur trifluoride; ammonia; hydrogen; hydrogen cation; potassium carbonate; ammonium chloride; triethylamine; Lindlar's catalyst; nickel; In 1,4-dioxane; ethanol; dichloromethane; water;
DOI:10.1039/c39900000151

Reference yield:

: 119895-90-8
triphenylmethoxymethylcyclopent-2-ene

: 129746-12-9,129829-88-5
[(1R,2S,3R)-3-(6-Amino-purin-9-yl)-2-fluoro-cyclopentyl]-methanol

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) dimethyldibromohydantoin, 2.) K₂CO₃ / 1.) H₂O, acetone, 0 deg C, 2.) MeOH

2: 84 percent / NaN₃, NH₄Cl / ethanol; H₂O / 90 °C

3: pyridine

4: Bu₄NF / tetrahydrofuran

5: 100 percent / H₂ / Lindlar catalyst / ethanol

6: 41 percent / Et₃N / CH₂Cl₂ / Ambient temperature

7: 77 percent / H₂ / Raney Ni / dioxane

8: H⁺

9: NH₃(l) / 18 h / Ambient temperature

10: aq. HCl / 0.08 h

With pyridine; hydrogenchloride; sodium azide; dimethyldibromohydantoin; tetrabutyl ammonium fluoride; ammonia; hydrogen; hydrogen cation; potassium carbonate; ammonium chloride; triethylamine; Lindlar's catalyst; nickel; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;
DOI:10.1039/c39900000151

Reference yield:

: 119895-91-9,129829-81-8,129829-82-9,137767-65-8,137767-66-9
2-exo-triphenylmethoxymethyl-6-oxabicyclo<3.1.0>hexane

: 129746-12-9,129829-88-5
[(1R,2R,3R)-3-(6-Amino-purin-9-yl)-2-fluoro-cyclopentyl]-methanol

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / NaN₃, NH₄Cl / ethanol; H₂O / 90 °C

2: diethylaminosulphur trifluoride (DAST) / CH₂Cl₂ / 0 °C

3: H₂ / Lindlar catalyst / ethanol

4: Et₃N / CH₂Cl₂ / Ambient temperature

5: H₂ / Raney Ni / dioxane

6: H⁺

7: NH₃(l) / 18 h / Ambient temperature

8: aq. HCl / 0.08 h

With hydrogenchloride; sodium azide; diethylamino-sulfur trifluoride; ammonia; hydrogen; hydrogen cation; ammonium chloride; triethylamine; Lindlar's catalyst; nickel; In 1,4-dioxane; ethanol; dichloromethane; water;
DOI:10.1039/c39900000151