1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid hydrochloride

Base Information

Chemical Name:1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid hydrochloride
CAS No.:1093213-76-3
Molecular Formula:C₂₇H₂₄FN₃O₃*ClH
Molecular Weight:493.965
Hs Code.:

Synonyms:1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid hydrochloride

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Chemical Property of 1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid hydrochloride

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Technology Process of 1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid hydrochloride

There total 4 articles about 1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093214-98-2
1-{4-[5-(2-fluorobiphenyl-4yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid ethyl ester

: 1093213-76-3
1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid hydrochloride

Guidance literature:: 1-{4-[5-(2-fluorobiphenyl-4yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid ethyl ester; With sodium hydroxide; water; In tetrahydrofuran; ethanol; at 85 ℃; for 6h; Heating / reflux;

With hydrogenchloride; In water; pH=~ 2;

Reference yield:

: N'-hydroxy-4-(hydroxymethyl)benzimidamide

: 1093213-76-3
1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 3 h / Heating / reflux

2.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0.5 h / 5 °C

2.2: 0.5 h / 80 °C

3.1: sodium hydroxide; water / tetrahydrofuran; ethanol / 6 h / 85 °C / Heating / reflux

3.2: pH ~ 2

With sodium hydroxide; water; benzotriazol-1-ol; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 455-24-3
4-trifluoromethylbenzoic acid

: 1093213-76-3
1-{4-[5-(2-fluorobiphenyl-4-yl)-[1,2,4]oxadiazol-3-yl]benzyl}piperidine-4-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 3 h / Heating / reflux

2.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0.5 h / 5 °C

2.2: 0.5 h / 80 °C

3.1: sodium hydroxide; water / tetrahydrofuran; ethanol / 6 h / 85 °C / Heating / reflux

3.2: pH ~ 2

With sodium hydroxide; water; benzotriazol-1-ol; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;