ethyl 4-carbobenzyloxy-5-methyl-3-n-propyl-1H-pyrrole-2-carboxylate

Base Information

• Chemical Name: ethyl 4-carbobenzyloxy-5-methyl-3-n-propyl-1H-pyrrole-2-carboxylate
• CAS No.: 943904-75-4
• Molecular Formula: C₁₉H₂₃NO₄
• Molecular Weight: 329.396
• Mol file: 943904-75-4.mol

Synonyms:ethyl 4-carbobenzyloxy-5-methyl-3-n-propyl-1H-pyrrole-2-carboxylate

Chemical Property of ethyl 4-carbobenzyloxy-5-methyl-3-n-propyl-1H-pyrrole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of ethyl 4-carbobenzyloxy-5-methyl-3-n-propyl-1H-pyrrole-2-carboxylate

There total 1 articles about ethyl 4-carbobenzyloxy-5-methyl-3-n-propyl-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

benzyl acetoacetate (5396-89-4) + ethyl butyroyl acetate (3249-68-1) → ethyl 4-carbobenzyloxy-5-methyl-3-n-propyl-1H-pyrrole-2-carboxylate (943904-75-4)

Guidance literature:

ethyl butyroyl acetate; With acetic acid; sodium nitrite; In water; at 5 - 20 ℃;

benzyl acetoacetate; With acetic acid; zinc; at 65 - 75 ℃; for 1.5h; Further stages.;

DOI:10.1002/jhet.5570440338

Reference yield: 11.25%

ethyl 4-carbobenzyloxy-5-methyl-3-n-propyl-1H-pyrrole-2-carboxylate (943904-75-4) → C19H21NO5 (943904-74-3) + 3-benzyloxycarbonyl-5-ethoxycarbonyl-4-propyl-1H-pyrrole-2-carboxylic acid (943904-73-2)

Guidance literature:

ethyl 4-carbobenzyloxy-5-methyl-3-n-propyl-1H-pyrrole-2-carboxylate; With sulfuryl dichloride; bromine; In acetic acid; at 10 - 20 ℃;

With water; In acetic acid; at 60 ℃; for 0.5h; Further stages.;

DOI:10.1002/jhet.5570440338

upstream raw materials:

benzyl acetoacetate

ethyl butyroyl acetate

Downstream raw materials:

C₁₉H₂₁NO₅

3-benzyloxycarbonyl-5-ethoxycarbonyl-4-propyl-1H-pyrrole-2-carboxylic acid