3-benzyloxycarbonyl-5-ethoxycarbonyl-4-propyl-1H-pyrrole-2-carboxylic acid

Base Information

• Chemical Name: 3-benzyloxycarbonyl-5-ethoxycarbonyl-4-propyl-1H-pyrrole-2-carboxylic acid
• CAS No.: 943904-73-2
• Molecular Formula: C₁₉H₂₁NO₆
• Molecular Weight: 359.379
• Mol file: 943904-73-2.mol

Synonyms:3-benzyloxycarbonyl-5-ethoxycarbonyl-4-propyl-1H-pyrrole-2-carboxylic acid

Chemical Property of 3-benzyloxycarbonyl-5-ethoxycarbonyl-4-propyl-1H-pyrrole-2-carboxylic acid

Chemical Property:

Purity/Quality:

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Technology Process of 3-benzyloxycarbonyl-5-ethoxycarbonyl-4-propyl-1H-pyrrole-2-carboxylic acid

There total 2 articles about 3-benzyloxycarbonyl-5-ethoxycarbonyl-4-propyl-1H-pyrrole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.25%

ethyl 4-carbobenzyloxy-5-methyl-3-n-propyl-1H-pyrrole-2-carboxylate (943904-75-4) → C19H21NO5 (943904-74-3) + 3-benzyloxycarbonyl-5-ethoxycarbonyl-4-propyl-1H-pyrrole-2-carboxylic acid (943904-73-2)

Guidance literature:

ethyl 4-carbobenzyloxy-5-methyl-3-n-propyl-1H-pyrrole-2-carboxylate; With sulfuryl dichloride; bromine; In acetic acid; at 10 - 20 ℃;

With water; In acetic acid; at 60 ℃; for 0.5h; Further stages.;

DOI:10.1002/jhet.5570440338

Reference yield:

C19H21NO5 (943904-74-3) → 3-benzyloxycarbonyl-5-ethoxycarbonyl-4-propyl-1H-pyrrole-2-carboxylic acid (943904-73-2)

Guidance literature:

With potassium permanganate; In water; acetone; at 20 ℃; for 10h;

DOI:10.1002/jhet.5570440338

Reference yield: 78.0%

3-benzyloxycarbonyl-5-ethoxycarbonyl-4-propyl-1H-pyrrole-2-carboxylic acid (943904-73-2) → ethyl 4-benzyloxycarbonyl-5-iodo-3-propyl-1H-pyrrole-2-carboxylate (943904-72-1)

Guidance literature:

With iodine; sodium hydrogencarbonate; potassium iodide; In ethanol; water; at 70 ℃;

DOI:10.1002/jhet.5570440338

upstream raw materials:

ethyl 4-carbobenzyloxy-5-methyl-3-n-propyl-1H-pyrrole-2-carboxylate

C₁₉H₂₁NO₅

Downstream raw materials:

5-ethoxycarbonyl-4-propyl-1H-pyrrole-2,3-dicarboxylic acid

ethyl 4-benzyloxycarbonyl-5-iodo-3-propyl-1H-pyrrole-2-carboxylate