ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-(trifluoromethyl)cinnamate

Base Information

Chemical Name:ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-(trifluoromethyl)cinnamate
CAS No.:1352042-55-7
Molecular Formula:C₃₅H₃₅F₃O₃
Molecular Weight:560.656
Hs Code.:

Synonyms:ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-(trifluoromethyl)cinnamate

Suppliers and Price of ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-(trifluoromethyl)cinnamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-(trifluoromethyl)cinnamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-(trifluoromethyl)cinnamate

There total 3 articles about ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-(trifluoromethyl)cinnamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1352042-48-8
ethyl (E)-4-bromo-3-(trifluoromethyl)cinnamate

: 221137-01-5
3-(1-adamantyl)-4-benzyloxyphenylboronic acid

: 1352042-55-7
ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-(trifluoromethyl)cinnamate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; for 18h; Reflux; Inert atmosphere;
DOI:10.1021/jm2011436

Reference yield:

: 393-36-2
4-bromo-3-(trifluoromethyl)aniline

: 1352042-55-7
ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-(trifluoromethyl)cinnamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; sodium nitrite / water / 0.97 h / 0 - 5 °C

1.2: 2.3 h / 0 - 100 °C

2.1: palladium diacetate; triethylamine; tris-(o-tolyl)phosphine / 3 h / 115 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane / 18 h / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; palladium diacetate; sodium carbonate; triethylamine; tris-(o-tolyl)phosphine; sodium nitrite; In 1,2-dimethoxyethane; water; 2.1: Mizoroki-Heck reaction / 3.1: Suzuki-Miyaura coupling;
DOI:10.1021/jm2011436

Reference yield:

: 364-11-4
1-bromo-4-iodo-2-(trifluoromethyl)benzene

: 1352042-55-7
ethyl (E)-4-[3-(1-adamantyl)-4-benzyloxyphenyl]-3-(trifluoromethyl)cinnamate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; triethylamine; tris-(o-tolyl)phosphine / 3 h / 115 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane / 18 h / Reflux; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; sodium carbonate; triethylamine; tris-(o-tolyl)phosphine; In 1,2-dimethoxyethane; 1: Mizoroki-Heck reaction / 2: Suzuki-Miyaura coupling;
DOI:10.1021/jm2011436