(2S,4R)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-4-[(5-methoxy-1H-pyrazole-3-carbonyl)amino]-2-methylpentanoic acid

Base Information

Chemical Name:(2S,4R)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-4-[(5-methoxy-1H-pyrazole-3-carbonyl)amino]-2-methylpentanoic acid
CAS No.:1562404-65-2
Molecular Formula:C₂₄H₂₅ClFN₃O₅
Molecular Weight:489.931
Hs Code.:

Synonyms:(2S,4R)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-4-[(5-methoxy-1H-pyrazole-3-carbonyl)amino]-2-methylpentanoic acid

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Chemical Property of (2S,4R)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-4-[(5-methoxy-1H-pyrazole-3-carbonyl)amino]-2-methylpentanoic acid

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Technology Process of (2S,4R)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-4-[(5-methoxy-1H-pyrazole-3-carbonyl)amino]-2-methylpentanoic acid

There total 8 articles about (2S,4R)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-4-[(5-methoxy-1H-pyrazole-3-carbonyl)amino]-2-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 881693-06-7
5-Methoxy-1H-pyrazole-3-carboxylic acid

: 1562405-00-8
(2S,4R)-4-amino-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-2-methylpentanoic acid ethyl ester

: 1562404-65-2
(2S,4R)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-4-[(5-methoxy-1H-pyrazole-3-carbonyl)amino]-2-methylpentanoic acid

Guidance literature:: 5-Methoxy-1H-pyrazole-3-carboxylic acid; (2S,4R)-4-amino-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-2-methylpentanoic acid ethyl ester; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 2h;

With sodium hydroxide; In tetrahydrofuran; at 40 ℃; for 48h;

Reference yield:

: 1562404-84-5
(2S,4R)-5-(4-bromophenyl)-4-t-butoxycarbonylamino-2-(hydroxymethyl)-2-methylpentanoic acid

: 1562404-65-2
(2S,4R)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-4-[(5-methoxy-1H-pyrazole-3-carbonyl)amino]-2-methylpentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 0.75 h / 90 °C / Sealed tube; Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 3 h / 60 °C

3.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h

3.2: 48 h / 40 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1383027-95-9
C₂₀H₂₄BrNO₇

: 1562404-65-2
(2S,4R)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-4-[(5-methoxy-1H-pyrazole-3-carbonyl)amino]-2-methylpentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

1.2: 3.5 h / -5 - 23 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 23 °C

3.1: water; samarium; iodine / tetrahydrofuran / 2 h / -70 - 23 °C / Inert atmosphere; Sealed tube

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 0.75 h / 90 °C / Sealed tube; Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 3 h / 60 °C

6.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h

6.2: 48 h / 40 °C

With hydrogenchloride; samarium; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; iodine; sodium carbonate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;