(2S,4R)-5-(4-bromophenyl)-4-t-butoxycarbonylamino-2-(hydroxymethyl)-2-methylpentanoic acid

Base Information

Chemical Name:(2S,4R)-5-(4-bromophenyl)-4-t-butoxycarbonylamino-2-(hydroxymethyl)-2-methylpentanoic acid
CAS No.:1562404-84-5
Molecular Formula:C₁₈H₂₆BrNO₅
Molecular Weight:416.312
Hs Code.:

Synonyms:(2S,4R)-5-(4-bromophenyl)-4-t-butoxycarbonylamino-2-(hydroxymethyl)-2-methylpentanoic acid

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Chemical Property of (2S,4R)-5-(4-bromophenyl)-4-t-butoxycarbonylamino-2-(hydroxymethyl)-2-methylpentanoic acid

Chemical Property:

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Technology Process of (2S,4R)-5-(4-bromophenyl)-4-t-butoxycarbonylamino-2-(hydroxymethyl)-2-methylpentanoic acid

There total 6 articles about (2S,4R)-5-(4-bromophenyl)-4-t-butoxycarbonylamino-2-(hydroxymethyl)-2-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1562404-79-8
[(R)-1-(4-bromobenzyl)-2-(2,2,5-trimethyl-4,6-dioxo-[1,3]dioxan-5-yl)ethyl]carbamic acid t-butyl ester

: 1562404-84-5
(2S,4R)-5-(4-bromophenyl)-4-t-butoxycarbonylamino-2-(hydroxymethyl)-2-methylpentanoic acid

Guidance literature:: With samarium; water; iodine; In tetrahydrofuran; at -70 - 23 ℃; for 2h; Inert atmosphere; Sealed tube;

Reference yield:

: 1383027-95-9
C₂₀H₂₄BrNO₇

: 1562404-84-5
(2S,4R)-5-(4-bromophenyl)-4-t-butoxycarbonylamino-2-(hydroxymethyl)-2-methylpentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

1.2: 3.5 h / -5 - 23 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 23 °C

3.1: water; samarium; iodine / tetrahydrofuran / 2 h / -70 - 23 °C / Inert atmosphere; Sealed tube

With samarium; water; iodine; potassium carbonate; acetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1394050-15-7
[(S)-1-(4-bromobenzyl)-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)ethyl]carbamic acid t-butyl ester

: 1562404-84-5
(2S,4R)-5-(4-bromophenyl)-4-t-butoxycarbonylamino-2-(hydroxymethyl)-2-methylpentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0 - 23 °C

2: water; samarium; iodine / tetrahydrofuran / 2 h / -70 - 23 °C / Inert atmosphere; Sealed tube

With samarium; water; iodine; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;