(2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid

Base Information

• Chemical Name: (2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid
• CAS No.: 579509-51-6
• Molecular Formula: C₂₄H₂₂N₂O₆
• Molecular Weight: 434.448

Synonyms:(2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid

Chemical Property of (2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid

Chemical Property:

Purity/Quality:

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Technology Process of (2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid

There total 2 articles about (2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid benzyl ester (579509-50-5) → (2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid (579509-51-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; for 5h;

DOI:10.1021/jo034150e

Reference yield:

1-(biphenyl-4-carbonyl)-3-(4-methoxy-phenoxy)-4-oxo-azetidine 2-carboxylic acid benzyl ester (579509-49-2) → (2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid (579509-51-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / liquid ammonia / CH₂Cl₂ / -78 - 20 °C

2: H₂ / Pd/C / ethanol; dimethylformamide / 5 h

With ammonia; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo034150e

Reference yield:

(2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid (579509-51-6) → 2-amino-3-(4-methoxy-phenoxy)-succinamic acid (579509-52-7)

Guidance literature:

With sodium amalgam; In methanol; for 2h;

DOI:10.1021/jo034150e

upstream raw materials:

(2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid benzyl ester

1-(biphenyl-4-carbonyl)-3-(4-methoxy-phenoxy)-4-oxo-azetidine 2-carboxylic acid benzyl ester

Downstream raw materials:

2-amino-3-(4-methoxy-phenoxy)-succinamic acid

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