(2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid benzyl ester

Base Information

Chemical Name:(2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid benzyl ester
CAS No.:579509-50-5
Molecular Formula:C₃₁H₂₈N₂O₆
Molecular Weight:524.573
Hs Code.:

Synonyms:(2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid benzyl ester

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Chemical Property of (2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid benzyl ester

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Technology Process of (2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid benzyl ester

There total 1 articles about (2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 579509-49-2
1-(biphenyl-4-carbonyl)-3-(4-methoxy-phenoxy)-4-oxo-azetidine 2-carboxylic acid benzyl ester

: 579509-50-5
(2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid benzyl ester

Guidance literature:: With ammonia; In dichloromethane; at -78 - 20 ℃;
DOI:10.1021/jo034150e

Reference yield:

: 579509-50-5
(2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid benzyl ester

: 579509-51-6
(2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; for 5h;
DOI:10.1021/jo034150e

Reference yield:

: 579509-50-5
(2R,3R)-2-[(Biphenyl-4-carbonyl)-amino]-3-(4-methoxy-phenoxy)-succinamic acid benzyl ester

: 579509-52-7
2-amino-3-(4-methoxy-phenoxy)-succinamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol; dimethylformamide / 5 h

2: Na/Hg amalgam / methanol / 2 h

With sodium amalgam; hydrogen; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jo034150e