(R)-2-Methyl-2-((S)-2-phenoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid tert-butyl ester

Base Information

Chemical Name:(R)-2-Methyl-2-((S)-2-phenoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid tert-butyl ester
CAS No.:110510-49-1
Molecular Formula:C₂₉H₃₃NO₄
Molecular Weight:459.585
Hs Code.:

Synonyms:(R)-2-Methyl-2-((S)-2-phenoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid tert-butyl ester

Suppliers and Price of (R)-2-Methyl-2-((S)-2-phenoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-Methyl-2-((S)-2-phenoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid tert-butyl ester

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of (R)-2-Methyl-2-((S)-2-phenoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid tert-butyl ester

There total 7 articles about (R)-2-Methyl-2-((S)-2-phenoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 110510-46-8
(R)-2-Methyl-2-((3S,4R)-2-oxo-3-phenoxy-4-phenyl-azetidin-1-yl)-3-phenyl-propionic acid tert-butyl ester

: 110510-49-1
(R)-2-Methyl-2-((S)-2-phenoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 50 ℃; for 8h;
DOI:10.1016/S0040-4020(01)86038-5

Reference yield:

: 102108-70-3
1-<(S)-1-(t-butoxycarbonyl)ethyl>-(3S,4R)-3-phenoxy-4-phenylazetidin-2-one

: 110510-49-1
(R)-2-Methyl-2-((S)-2-phenoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium diisopropylamide / 1.) THF, 0 deg C, 15 min, 2.) THF, -78 deg C, 5 h

2: H₂ / Pd-C

With hydrogen; lithium diisopropyl amide; palladium on activated charcoal;
DOI:10.1021/ja00255a063

Reference yield:

: 100-39-0
benzyl bromide

: 110510-49-1
(R)-2-Methyl-2-((S)-2-phenoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium diisopropylamide / 1.) THF, 0 deg C, 15 min, 2.) THF, -78 deg C, 5 h

2: H₂ / Pd-C

With hydrogen; lithium diisopropyl amide; palladium on activated charcoal;
DOI:10.1021/ja00255a063