2-Amino-N-((1-butyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide

Base Information

Chemical Name:2-Amino-N-((1-butyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide
CAS No.:72412-49-8
Molecular Formula:C₁₅H₂₅N₅O₂
Molecular Weight:307.396
Hs Code.:
DSSTox Substance ID:DTXSID10993217
Nikkaji Number:J70.317F
Mol file:72412-49-8.mol

Synonyms:72412-49-8;BRN 5580628;2-Amino-N-((1-butyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide;5-Pyrimidinecarboxamide, 2-amino-N-((1-butyl-2-pyrrolidinyl)methyl)-4-methoxy-;2-Amino-N-[(1-butyl-2-pyrrolidinyl)methyl]-4-methoxy-5-pyrimidinecarboxamide;DTXSID10993217;C15H25N5O2;LS-134721;N-[(1-Butylpyrrolidin-2-yl)methyl]-2-imino-4-methoxy-1,2-dihydropyrimidine-5-carboximidic acid

Suppliers and Price of 2-Amino-N-((1-butyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-AMINO-N-((1-BUTYL-2-PYRROLIDINYL)METHYL)-4-METHOXY-5-PYRIMIDINECARBOXAMIDE 95.00%
5MG
$ 503.68

Total 1 raw suppliers

Chemical Property of 2-Amino-N-((1-butyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide

Chemical Property:

PSA：97.59000
Density:1.143g/cm³
LogP:1.50450
XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:307.20082506
Heavy Atom Count:22
Complexity:355

Purity/Quality:: 2-AMINO-N-((1-BUTYL-2-PYRROLIDINYL)METHYL)-4-METHOXY-5-PYRIMIDINECARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCN1CCCC1CNC(=O)C2=CN=C(N=C2OC)N

Technology Process of 2-Amino-N-((1-butyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide

There total 5 articles about 2-Amino-N-((1-butyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15400-53-0
ethyl 2-amino-4-hydroxypyrimidine-5-carboxylate

: 72412-49-8
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid (1-butyl-pyrrolidin-2-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / pyridine / 2 h / Heating

2: 81 percent / phosphorus oxychloride / 2 h / 60 °C

3: 95 percent / sodium / Ambient temperature

4: 77 percent / NaOH / methanol; H₂O / 1 h / 65 °C

5: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; trichlorophosphate; In pyridine; methanol; water;

Reference yield:

: 72419-36-4
2-amino-4-methoxy-5-methoxycarbonilpyrimidine

: 72412-49-8
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid (1-butyl-pyrrolidin-2-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / NaOH / methanol; H₂O / 1 h / 65 °C

2: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.

With sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In methanol; water;

Reference yield:

: 344311-74-6
2-Acetylamino-4-hydroxy-pyrimidine-5-carboxylic acid ethyl ester

: 72412-49-8
2-Amino-4-methoxy-pyrimidine-5-carboxylic acid (1-butyl-pyrrolidin-2-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / phosphorus oxychloride / 2 h / 60 °C

2: 95 percent / sodium / Ambient temperature

3: 77 percent / NaOH / methanol; H₂O / 1 h / 65 °C

4: 1.) triethylamine, ethylchloroformate / 1.) DMF, 0 deg C, 30 min, 2.) room temp.

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; trichlorophosphate; In methanol; water;