Imidazo[2,1-b]thiazol-6-yl-acetic acid ethyl ester

Base Information

• Chemical Name: Imidazo[2,1-b]thiazol-6-yl-acetic acid ethyl ester
• CAS No.: 57332-73-7
• Molecular Formula: C9H10N2O2S
• Molecular Weight: 210.25
• Hs Code.: 2934100090
• European Community (EC) Number: 861-440-4
• DSSTox Substance ID: DTXSID70357452
• Wikidata: Q82137356
• Mol file: 57332-73-7.mol

Synonyms:57332-73-7;Imidazo[2,1-b]thiazol-6-yl-acetic acid ethyl ester;ethyl 2-{imidazo[2,1-b][1,3]thiazol-6-yl}acetate;ethyl 2-imidazo[2,1-b][1,3]thiazol-6-ylacetate;Ethyl 2-(imidazo[2,1-b]thiazol-6-yl)acetate;imidazo(2,1-b)thiazol-6-yl-acetic acid ethyl ester;Enamine_001240;DTXSID70357452;HMS1397I08;MFCD00225160;AKOS000121738;CS-0218377;EN300-00710;Ethyl imidazo[2,1-b][1,3]thiazol-6-ylacetate;Z54529092;F2124-0495

Chemical Property of Imidazo[2,1-b]thiazol-6-yl-acetic acid ethyl ester

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 71.84000
• Density: 1.37g/cm³
• LogP: 1.50140
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 210.04629874
• Heavy Atom Count: 14
• Complexity: 225

Purity/Quality:

99% ^*data from raw suppliers

ethyl2-{imidazo[2,1-b][1,3]thiazol-6-yl}acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)CC1=CN2C=CSC2=N1

Technology Process of Imidazo[2,1-b]thiazol-6-yl-acetic acid ethyl ester

There total 3 articles about Imidazo[2,1-b]thiazol-6-yl-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

2-thiazolylamine (96-50-4) + 4-bromoethyl acetoacetate (13176-46-0) → ethyl imidazo<2,1-b>thiazole-6-acetate (57332-73-7)

Guidance literature:

In ethanol; for 16h; Heating;

DOI:10.1016/0223-5234(96)88309-7

Reference yield:

2-amino-3-(3-ethoxycarbonyl-2-oxo-propyl)-thiazolium; bromide (57626-34-3) → ethyl imidazo<2,1-b>thiazole-6-acetate (57332-73-7)

Guidance literature:

In ethanol; for 2h; Heating;

Reference yield:

→ ethyl imidazo<2,1-b>thiazole-6-acetate (57332-73-7)

Guidance literature:

upstream raw materials:

2-thiazolylamine

4-bromoethyl acetoacetate

2-amino-3-(3-ethoxycarbonyl-2-oxo-propyl)-thiazolium; bromide

Downstream raw materials:

imidazo<2,1-b>thiazole-6-acetic acid

Refernces

• 1、 -. "1,2-disubstituted-6-oxo-3-phenyl-piperidine-3-carboxamides and combinatorial libraries thereof". . . Retrieved 2008/06/13.
• 2、 Abignente,Arena,De Caprariis,Parente. "Research on heterocyclic compounds. V". . p. 880 - 887. Retrieved 2007/10/05.