C₁₉H₁₅F₃N₄O₂S

Base Information

• Chemical Name: C₁₉H₁₅F₃N₄O₂S
• CAS No.: 1569653-73-1
• Molecular Formula: C₁₉H₁₅F₃N₄O₂S
• Molecular Weight: 420.415
• Mol file: 1569653-73-1.mol

Synonyms:C₁₉H₁₅F₃N₄O₂S

Chemical Property of C₁₉H₁₅F₃N₄O₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₁₉H₁₅F₃N₄O₂S

There total 4 articles about C₁₉H₁₅F₃N₄O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H14N4O2S (1569656-51-4) + (trifluoromethyl)trimethylsilane (81290-20-2) → C19H15F3N4O2S (1569653-73-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

2-<(N-methylamino)methyl>thiazole (144163-68-8) → C19H15F3N4O2S (1569653-73-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 100 °C / Inert atmosphere; Sealed tube

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 85 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; sodium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane;

Reference yield:

C11H9BrN4OS (1569653-80-0) → C19H15F3N4O2S (1569653-73-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 85 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; sodium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane;

upstream raw materials:

2-<(N-methylamino)methyl>thiazole

C₁₁H₉BrN₄OS

C₁₈H₁₄N₄O₂S

(trifluoromethyl)trimethylsilane