5-(2,3-dimethoxy-5-methyl-phenyl)-5-methyl-hepta-1,6-dien-3-ol

Base Information

• Chemical Name: 5-(2,3-dimethoxy-5-methyl-phenyl)-5-methyl-hepta-1,6-dien-3-ol
• CAS No.: 433732-74-2
• Molecular Formula: C₁₇H₂₄O₃
• Molecular Weight: 276.376
• Mol file: 433732-74-2.mol

Synonyms:5-(2,3-dimethoxy-5-methyl-phenyl)-5-methyl-hepta-1,6-dien-3-ol

Chemical Property of 5-(2,3-dimethoxy-5-methyl-phenyl)-5-methyl-hepta-1,6-dien-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2,3-dimethoxy-5-methyl-phenyl)-5-methyl-hepta-1,6-dien-3-ol

There total 4 articles about 5-(2,3-dimethoxy-5-methyl-phenyl)-5-methyl-hepta-1,6-dien-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

vinyl magnesium bromide (1826-67-1) + 3-(2,3-dimethoxy-5-methyl-phenyl)-3-methyl-pent-4-enal (433732-71-9) → 5-(2,3-dimethoxy-5-methyl-phenyl)-5-methyl-hepta-1,6-dien-3-ol (433732-74-2)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1055/s-2002-19750

Reference yield:

2,3-dimethoxy-5-methylacetophenone → 5-(2,3-dimethoxy-5-methyl-phenyl)-5-methyl-hepta-1,6-dien-3-ol (433732-74-2)

Guidance literature:

Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran

2: LiAlH₄ / diethyl ether / 2 h / -70 °C

3: Hg(OAc)2 / 48 h / 180 °C

4: 92 percent / tetrahydrofuran / 1 h / 20 °C

With lithium aluminium tetrahydride; mercury(II) diacetate; sodium hydride; In tetrahydrofuran; diethyl ether; 1: Horner-Wadsworth-Emmons reaction / 3: Claisen rearrangement;

DOI:10.1055/s-2002-19750

Reference yield:

(E)-3-(2,3-Dimethoxy-5-methyl-phenyl)-but-2-en-1-ol (433732-68-4) → 5-(2,3-dimethoxy-5-methyl-phenyl)-5-methyl-hepta-1,6-dien-3-ol (433732-74-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Hg(OAc)2 / 48 h / 180 °C

2: 92 percent / tetrahydrofuran / 1 h / 20 °C

With mercury(II) diacetate; In tetrahydrofuran; 1: Claisen rearrangement;

DOI:10.1055/s-2002-19750

upstream raw materials:

vinyl magnesium bromide

3-(2,3-dimethoxy-5-methyl-phenyl)-3-methyl-pent-4-enal

(E)-3-(2,3-Dimethoxy-5-methyl-phenyl)-but-2-en-1-ol

(E)-3-(2,3-Dimethoxy-5-methyl-phenyl)-but-2-enoic acid ethyl ester

Downstream raw materials:

4-(2,3-dimethoxy-5-methyl-phenyl)-4-methyl-cyclopent-2-enol

4-(2,3-dimethoxy-5-methyl-phenyl)-4-methyl-cyclopent-2-enone