2-(5-{2-(tert-butyl-dimethyl-silanyloxy)-3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid 1-{1-[5-(1-benzyloxycarbonyl-ethyl)-tetrahydro-furan-2-yl]-ethyl}-butyl ester

Base Information

Chemical Name:2-(5-{2-(tert-butyl-dimethyl-silanyloxy)-3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid 1-{1-[5-(1-benzyloxycarbonyl-ethyl)-tetrahydro-furan-2-yl]-ethyl}-butyl ester
CAS No.:870452-56-5
Molecular Formula:C₄₉H₈₅NO₈Si
Molecular Weight:844.301
Hs Code.:

2-(5-{2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid 1-{1-[5-(1-benzyloxycarbonyl-ethyl)-tetrahydro-furan-2-yl]-ethyl}-butyl ester

Synonyms:2-(5-{2-(tert-butyl-dimethyl-silanyloxy)-3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid 1-{1-[5-(1-benzyloxycarbonyl-ethyl)-tetrahydro-furan-2-yl]-ethyl}-butyl ester

Suppliers and Price of 2-(5-{2-(tert-butyl-dimethyl-silanyloxy)-3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid 1-{1-[5-(1-benzyloxycarbonyl-ethyl)-tetrahydro-furan-2-yl]-ethyl}-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(5-{2-(tert-butyl-dimethyl-silanyloxy)-3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid 1-{1-[5-(1-benzyloxycarbonyl-ethyl)-tetrahydro-furan-2-yl]-ethyl}-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(5-{2-(tert-butyl-dimethyl-silanyloxy)-3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid 1-{1-[5-(1-benzyloxycarbonyl-ethyl)-tetrahydro-furan-2-yl]-ethyl}-butyl ester

There total 6 articles about 2-(5-{2-(tert-butyl-dimethyl-silanyloxy)-3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid 1-{1-[5-(1-benzyloxycarbonyl-ethyl)-tetrahydro-furan-2-yl]-ethyl}-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 870452-47-4
(S)-2-[(2R,5S)-5-((1S,2S)-2-Hydroxy-1-methyl-pentyl)-tetrahydro-furan-2-yl]-propionic acid benzyl ester

: 393589-25-8
(R)-2-((2R,5S)-5-{(1R,2S,3R)-2-(tert-Butyl-dimethyl-silanyloxy)-3-[(2R,5S)-5-((R)-2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid

: 870452-56-5
2-(5-{2-(tert-butyl-dimethyl-silanyloxy)-3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid 1-{1-[5-(1-benzyloxycarbonyl-ethyl)-tetrahydro-furan-2-yl]-ethyl}-butyl ester

Guidance literature:: (R)-2-((2R,5S)-5-{(1R,2S,3R)-2-(tert-Butyl-dimethyl-silanyloxy)-3-[(2R,5S)-5-((R)-2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid; With 2,4,6-trichlorobenzoyl chloride; triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

(S)-2-[(2R,5S)-5-((1S,2S)-2-Hydroxy-1-methyl-pentyl)-tetrahydro-furan-2-yl]-propionic acid benzyl ester; With dmap; In toluene; at 20 ℃;
DOI:10.1002/anie.200501511

Reference yield:

: 4,6-dimethyl-1,1-dioxo-3-propyl-3,4,6,7,8,8a-hexahydro-1H-1λ⁶-benzo[c][1,2]oxathiin-7-ol

: 870452-56-5
2-(5-{2-(tert-butyl-dimethyl-silanyloxy)-3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid 1-{1-[5-(1-benzyloxycarbonyl-ethyl)-tetrahydro-furan-2-yl]-ethyl}-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: ozone; NaHCO₃ / CH₂Cl₂ / -78 °C

1.2: 87 percent / acetic anhydride; pyridine / CH₂Cl₂ / Heating

2.1: 79 percent / BF₃*Et₂O / CH₂Cl₂ / 20 °C

3.1: 59 percent / H₂ / Raney Ni / ethanol / 20 °C / 37503 Torr

4.1: 100 percent / sodium hydroxide / 20 °C

5.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 20 °C

5.2: 65 percent / 4-(N,N-dimethylamino)pyridine / toluene / Heating

6.1: 59 percent / PhCH₂OLi / tetrahydrofuran / 20 °C

7.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 0 - 20 °C

7.2: 94 percent / 4-(N,N-dimethylamino)pyridine / toluene / 20 °C

With sodium hydroxide; 2,4,6-trichlorobenzoyl chloride; boron trifluoride diethyl etherate; lithium benzyloxide; hydrogen; sodium hydrogencarbonate; ozone; triethylamine; nickel; In tetrahydrofuran; ethanol; dichloromethane; 5.1: Yamaguchi lactonization / 7.1: Yamaguchi coupling;
DOI:10.1002/anie.200501511

Reference yield:

: 870452-53-2
(R)-2-((2R,6S,7S)-7-Methyl-4,4-dioxo-7a-phenylsulfanyl-6-propyl-hexahydro-1,5-dioxa-4λ⁶-thia-inden-2-yl)-propionic acid methyl ester

: 870452-56-5
2-(5-{2-(tert-butyl-dimethyl-silanyloxy)-3-[5-(2-dimethylamino-pentyl)-tetrahydro-furan-2-yl]-1-methyl-butyl}-tetrahydro-furan-2-yl)-propionic acid 1-{1-[5-(1-benzyloxycarbonyl-ethyl)-tetrahydro-furan-2-yl]-ethyl}-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 59 percent / H₂ / Raney Ni / ethanol / 20 °C / 37503 Torr

2.1: 100 percent / sodium hydroxide / 20 °C

3.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 20 °C

3.2: 65 percent / 4-(N,N-dimethylamino)pyridine / toluene / Heating

4.1: 59 percent / PhCH₂OLi / tetrahydrofuran / 20 °C

5.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 0 - 20 °C

5.2: 94 percent / 4-(N,N-dimethylamino)pyridine / toluene / 20 °C

With sodium hydroxide; 2,4,6-trichlorobenzoyl chloride; lithium benzyloxide; hydrogen; triethylamine; nickel; In tetrahydrofuran; ethanol; 3.1: Yamaguchi lactonization / 5.1: Yamaguchi coupling;
DOI:10.1002/anie.200501511