1-((3-(4-bromophenoxy)propyl)(4-fluorobenzyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Base Information

Chemical Name:1-((3-(4-bromophenoxy)propyl)(4-fluorobenzyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol
CAS No.:1354972-09-0
Molecular Formula:C₂₇H₂₆BrF₃N₄O₂
Molecular Weight:575.428
Hs Code.:

Synonyms:1-((3-(4-bromophenoxy)propyl)(4-fluorobenzyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

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Chemical Property of 1-((3-(4-bromophenoxy)propyl)(4-fluorobenzyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

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Technology Process of 1-((3-(4-bromophenoxy)propyl)(4-fluorobenzyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

There total 3 articles about 1-((3-(4-bromophenoxy)propyl)(4-fluorobenzyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.1%

: 1354971-90-6
1-((3-(4-bromophenoxy)propyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

: 1354972-09-0
1-((3-(4-bromophenoxy)propyl)(4-fluorobenzyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; for 8h; Reflux;
DOI:10.1016/j.ejmech.2012.04.013

Reference yield:

: 1354972-28-3
3-(4-bromophenoxy)propan-1-amine hydrochloride

: 1354972-09-0
1-((3-(4-bromophenoxy)propyl)(4-fluorobenzyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / 8 h / Reflux

2: potassium carbonate; potassium iodide / acetonitrile / 8 h / Reflux

With potassium carbonate; triethylamine; potassium iodide; In ethanol; acetonitrile;
DOI:10.1016/j.ejmech.2012.04.013

Reference yield:

: 106-41-2
4-bromo-phenol

: 1354972-09-0
1-((3-(4-bromophenoxy)propyl)(4-fluorobenzyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / ethanol / 4 h / 80 °C

2: sodium azide / dimethyl sulfoxide / 12 h / 20 °C

3: triphenylphosphine / methanol / 5 h / Reflux

4: triethylamine / ethanol / 8 h / Reflux

5: potassium carbonate; potassium iodide / acetonitrile / 8 h / Reflux

With sodium azide; potassium carbonate; triethylamine; triphenylphosphine; potassium iodide; In methanol; ethanol; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.ejmech.2012.04.013