1-((3-(4-bromophenoxy)propyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Base Information

Chemical Name:1-((3-(4-bromophenoxy)propyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol
CAS No.:1354971-90-6
Molecular Formula:C₂₀H₂₁BrF₂N₄O₂
Molecular Weight:467.313
Hs Code.:

Synonyms:1-((3-(4-bromophenoxy)propyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

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Chemical Property of 1-((3-(4-bromophenoxy)propyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

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Technology Process of 1-((3-(4-bromophenoxy)propyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

There total 4 articles about 1-((3-(4-bromophenoxy)propyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.1%

: 1354972-28-3
3-(4-bromophenoxy)propan-1-amine hydrochloride

: 86386-77-8
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate

: 1354971-90-6
1-((3-(4-bromophenoxy)propyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Guidance literature:: With triethylamine; In ethanol; for 8h; Reflux;
DOI:10.1016/j.ejmech.2012.04.013

Reference yield:

: 106-41-2
4-bromo-phenol

: 1354971-90-6
1-((3-(4-bromophenoxy)propyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / ethanol / 4 h / 80 °C

2: sodium azide / dimethyl sulfoxide / 12 h / 20 °C

3: triphenylphosphine / methanol / 5 h / Reflux

4: triethylamine / ethanol / 8 h / Reflux

With sodium azide; potassium carbonate; triethylamine; triphenylphosphine; In methanol; ethanol; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2012.04.013

Reference yield:

: 1250125-40-6
1-(3-azidopropoxy)-4-bromobenzene

: 1354971-90-6
1-((3-(4-bromophenoxy)propyl)amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine / methanol / 5 h / Reflux

2: triethylamine / ethanol / 8 h / Reflux

With triethylamine; triphenylphosphine; In methanol; ethanol;
DOI:10.1016/j.ejmech.2012.04.013