2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol

Base Information

Chemical Name:2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol
CAS No.:1361570-73-1
Molecular Formula:C₁₇H₁₁FN₆O₃
Molecular Weight:366.311
Hs Code.:

Synonyms:2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol

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Chemical Property of 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol

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Technology Process of 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol

There total 1 articles about 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 20139-83-7
ethyl 3-(dimethylamino)-2-nitroacrylate

: 256499-19-1
1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide hydrochloride

: 1361570-73-1
2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol

Guidance literature:: In para-xylene; for 6h; Reflux;

Reference yield: 62.0%

: 1361570-73-1
2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol

: 1361570-74-2
3-(4-chloro-5-nitropyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: With trichlorophosphate; In sulfolane; at 120 ℃; for 1h;

Reference yield:

: 1361570-73-1
2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol

: 1361570-81-1
9-(2,4-dimethoxybenzyl)-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7-(oxetan-2-ylmethyl)-7,9-dihydro-8H-purin-8-one

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / sulfolane / 1 h / 120 °C

2: diisopropylamine / 1,4-dioxane / 1 h / 85 °C

3: pyridine; palladium 10% on activated carbon; hydrogen / 2 h / 20 °C

4: acetonitrile / 4 h / Reflux

5: caesium carbonate / N,N-dimethyl-formamide / 40 h / 20 - 100 °C

With pyridine; palladium 10% on activated carbon; hydrogen; caesium carbonate; diisopropylamine; trichlorophosphate; In 1,4-dioxane; sulfolane; N,N-dimethyl-formamide; acetonitrile;