256499-19-1

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride is used as a key intermediate for the synthesis of Riociguat, a potent oral stimulator of soluble guanylate cyclase. Riociguat is specifically designed for the treatment of pulmonary hypertension, a severe and life-threatening condition characterized by high blood pressure in the arteries of the lungs. The compound contributes to the development of innovative therapies for patients suffering from this disease.

Upstream product

• 117007-52-0 3-iodo-1H-pyrazolo[3,4-b]pyridine 
• 446-48-0 o-fluorobenzyl bromide 
• 1313738-72-5 1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine 
• 256376-68-8 please input 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-formamidine 
• 256376-65-5 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 
• 304874-06-4 methyl 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbimidate 

Downstream Products

• 671241-02-4 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(1-oxido-4-pyridinyl)-4-pyrimidinylamine 
• 370879-49-5 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-[(E)-phenyldiazen-1-yl]pyrimidine-4,6-diamine 
• 1361570-98-0 methyl 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-hydroxypyrimidine-5-carboxylate 
• 1344670-06-9 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidohydrazide 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF METHYL 4,6-DIAMINO-2-[L-(2-FHIOROBENZVR)-LH-PYRAZOLO I3,4-BLPVRIDIN-3-VN-5-PYRIMIDINYL(METHVL)CARBAMATE AND ITS POLYMORPHS THEREOF

The present invention relates to process for the preparation of methyl 4,6-diamino-2-[1-(2-fluorobenzyl)-lH-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl(methyl)carbamate and its polymorphs thereof compound of formula-1, represented by the following structur

METHOD FOR SYNTHESIZING 1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDINE-3-FORMAMIDINE HYDROCHLORIDE

The present invention relates to the field of chemical synthesis, and in particular to a method for synthesizing 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-formamidine hydrochloride, which is an important intermediate of Riociguat that is an anti-thro

PYRIDINE-SUBSTITUTED PYRAZOLOPYRIDINE DERIVATIVE

The invention relates to a substituted pyrazole derivative and the use thereof as a medicament, particularly as a medicament for treating cardiovascular diseases.