5-(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)-4-(2-phenylethyl)-1,3-thiazol-2-amine

Base Information

Chemical Name:5-(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)-4-(2-phenylethyl)-1,3-thiazol-2-amine
CAS No.:890414-20-7
Molecular Formula:C₂₀H₃₂N₂OSSi
Molecular Weight:376.638
Hs Code.:

Synonyms:5-(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)-4-(2-phenylethyl)-1,3-thiazol-2-amine

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Chemical Property of 5-(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)-4-(2-phenylethyl)-1,3-thiazol-2-amine

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Technology Process of 5-(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)-4-(2-phenylethyl)-1,3-thiazol-2-amine

There total 6 articles about 5-(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)-4-(2-phenylethyl)-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 890414-18-3
3-[2-amino-4-(2-phenylethyl)-1,3-thiazol-5-yl]propan-1-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 890414-20-7
5-(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)-4-(2-phenylethyl)-1,3-thiazol-2-amine

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1007/s00044-005-0126-y

Reference yield:

: 102-92-1,17082-09-6
Cinnamoyl chloride

: 890414-20-7
5-(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)-4-(2-phenylethyl)-1,3-thiazol-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / DIBAL-H / Pd(PPh₃)2Cl₂ / tetrahydrofuran / 2 h / 0 °C

2: 72 percent / CuBr₂ / ethyl acetate; CHCl₃ / 1 h / 55 °C

3: 95 percent / acetone / 12 h / Heating

4: 71 percent / p-toluene sulfonylhydrazide; sodium acetate trihydrate / tetrahydrofuran; H₂O / 5 h / Heating

5: 65 percent / LiAlH₄ / diethyl ether / 2 h / 20 °C

6: 90 percent / imidazole / CH₂Cl₂ / 5 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; sodium acetate; diisobutylaluminium hydride; toluene-4-sulfonic acid hydrazide; copper(ll) bromide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; water; ethyl acetate; acetone; 1: Reformatsky reaction / 3: Hantzsch reaction;
DOI:10.1007/s00044-005-0126-y

Reference yield:

: 890414-10-5
ethyl (6E)-5-oxo-7-phenylhept-6-enoate

: 890414-20-7
5-(3-{[tert-butyl(dimethyl)silyl]oxy}propyl)-4-(2-phenylethyl)-1,3-thiazol-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / CuBr₂ / ethyl acetate; CHCl₃ / 1 h / 55 °C

2: 95 percent / acetone / 12 h / Heating

3: 71 percent / p-toluene sulfonylhydrazide; sodium acetate trihydrate / tetrahydrofuran; H₂O / 5 h / Heating

4: 65 percent / LiAlH₄ / diethyl ether / 2 h / 20 °C

5: 90 percent / imidazole / CH₂Cl₂ / 5 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; sodium acetate; toluene-4-sulfonic acid hydrazide; copper(ll) bromide; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; water; ethyl acetate; acetone; 2: Hantzsch reaction;
DOI:10.1007/s00044-005-0126-y