2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamic acid

Base Information

Chemical Name:2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamic acid
CAS No.:114155-68-9
Molecular Formula:C₂₀H₂₃NO₄S
Molecular Weight:373.473
Hs Code.:

Synonyms:2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamic acid

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Chemical Property of 2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamic acid

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Technology Process of 2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamic acid

There total 4 articles about 2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 35638-70-1
lithium methanethiolate

: 114155-67-8
α-benzyl-α-<(benzyloxycarbonyl)amino>-γ-butyrolactone

: 114155-68-9
2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamic acid

Guidance literature:: In N,N,N,N,N,N-hexamethylphosphoric triamide; for 96h; Ambient temperature;
DOI:10.1021/jm00402a021

Reference yield:

: 116650-55-6
α-benzyl-α-amino-γ-butyrolactone

: 114155-68-9
2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / sodium carbonate / tetrahydrofuran / 18 h / Ambient temperature

2: 88 percent / hexamethylphosphoric acid triamide / 96 h / Ambient temperature

With sodium carbonate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/jm00402a021

Reference yield:

: 100-52-7
benzaldehyde

: 114155-68-9
2-<(benzyloxycarbonyl)amino>-2-<(methylthio)ethyl>hydrocinnamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / Et₃N, MgSO₄ / CH₂Cl₂ / 20 h / Ambient temperature

2: 1.) lithium diisopropylamide / 1) THF, hexane, -78 deg C, 15 min; 2) THF, hexane room temperature, 24 h

3: 99 percent / sodium carbonate / tetrahydrofuran / 18 h / Ambient temperature

4: 88 percent / hexamethylphosphoric acid triamide / 96 h / Ambient temperature

With sodium carbonate; magnesium sulfate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1021/jm00402a021