((1S,3R,4R,7S)-3-(6-amino-2-morpholino-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methanol

Base Information

Chemical Name:((1S,3R,4R,7S)-3-(6-amino-2-morpholino-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methanol
CAS No.:1341074-28-9
Molecular Formula:C₂₂H₂₆N₆O₅
Molecular Weight:454.486
Hs Code.:

Synonyms:((1S,3R,4R,7S)-3-(6-amino-2-morpholino-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methanol

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Chemical Property of ((1S,3R,4R,7S)-3-(6-amino-2-morpholino-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methanol

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Technology Process of ((1S,3R,4R,7S)-3-(6-amino-2-morpholino-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methanol

There total 5 articles about ((1S,3R,4R,7S)-3-(6-amino-2-morpholino-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₈H₄₄N₆O₅Si

: 1341074-28-9
((1S,3R,4R,7S)-3-(6-amino-2-morpholino-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methanol

Guidance literature:: With pyridine hydrogenfluoride; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.07.022

Reference yield:

: 1341075-09-9
(2R,3R,4S,5S)-2-(6-amino-2-fluoro-9H-purin-9-yl)-4-(benzyloxy)-5-((tert-butyldiphenylsilyloxy)methyl)-5-(tosyloxymethyl)tetrahydrofuran-3-yl acetate

: 1341074-28-9
((1S,3R,4R,7S)-3-(6-amino-2-morpholino-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / tetrahydrofuran; water / 15 h / 0 - 25 °C / Inert atmosphere

2: dimethyl sulfoxide / 24 h / 95 °C / Inert atmosphere

3: pyridine hydrogenfluoride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With pyridine hydrogenfluoride; sodium hydroxide; In tetrahydrofuran; water; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2011.07.022

Reference yield:

: 1341075-12-4
9-((1R,3R,4R,7S)-7-(benzyloxy)-1-((tert-butyldiphenylsilyloxy)methyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl)-2-fluoro-9H-purin-6-amine

: 1341074-28-9
((1S,3R,4R,7S)-3-(6-amino-2-morpholino-9H-purin-9-yl)-7-(benzyloxy)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 24 h / 95 °C / Inert atmosphere

2: pyridine hydrogenfluoride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With pyridine hydrogenfluoride; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2011.07.022